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Title: Prevalence of post-traumatic stress symptoms and its associations with quality of life, demographic and clinical characteristics in COVID-19 survivors during the post-COVID-19 era
Authors: Yuan, Y
Liu, ZH
Zhao, YJ
Zhang, Q
Zhang, L
Cheung, T 
Jackson, T
Jiang, GQ
Xiang, YT
Issue Date: May-2021
Source: Frontiers in psychiatry, May 2021, v. 12, 665507
Abstract: Background: The prevalence of post-traumatic stress symptoms (PTSS) in COVID-19 survivors is unclear. This study examined the prevalence of PTSS and its association with quality of life (QOL) among COVID-19 survivors during the post-COVID-19 era in China.
Methods: This was a comparative, cross-sectional study. PTSS, depressive symptoms, and QOL were assessed with standardized instruments.
Results: A total of 134 COVID-19 survivors and 214 non-infected controls (healthy controls hereafter) were recruited. Among COVID-19 survivors, the PTSS prevalence was 18.66% (95%CI: 11.98–25.34%), which was significantly higher than that (5.61%, 95%CI: 2.50–8.71%) of healthy controls (P < 0.001). After controlling for covariates, an analysis of covariance (ANCOVA) showed that COVID-19 survivors had a higher PTSS total score than did healthy controls [F(1,348) = 4.664, P = 0.032]. A separate ANCOVA revealed there were no significant differences in overall QOL between COVID-19 survivors with and without PTSS [F(1,348) = 1.067, P = 0.304]. A multiple logistic regression analysis showed that more severe depressive symptoms were significantly associated with PTSS in COVID-19 survivors (OR = 1.425, P < 0.001).
Conclusions: PTSS were more severe in COVID-19 survivors compared to healthy controls in the post-COVID-19 era. Considering their negative impact on daily life and functional outcomes, regular assessment and appropriate treatments of PTSS should be conducted in COVID-19 survivors.
Keywords: COVID-19 survivors
Depressive symptoms
Post-COVID-19 era
Quality of life
Publisher: Frontiers Research Foundation
Journal: Frontiers in psychiatry 
EISSN: 1664-0640
DOI: 10.3389/fpsyt.2021.665507
Rights: © 2021 Yuan, Liu, Zhao, Zhang, Zhang, Cheung, Jackson, Jiang and Xiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) ( The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
The following publication Yuan Y, Liu Z-H, Zhao Y-J, Zhang Q, Zhang L, Cheung T, Jackson T, Jiang G-Q and Xiang Y-T (2021) Prevalence of Post-traumatic Stress Symptoms and Its Associations With Quality of Life, Demographic and Clinical Characteristics in COVID-19 Survivors During the Post-COVID-19 Era. Front. Psychiatry 12:665507 is available at
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