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Title: In vivo photoacoustic imaging for monitoring treatment outcome of corneal neovascularization with metformin eye drops
Authors: Lui, KH 
Li, S 
Lo, WS 
Gu, Y 
Wong, WT 
Issue Date: Jun-2021
Source: Biomedical optics express, 1 June 2021, v. 12, no. 6, p. 3597-3606
Abstract: Corneal neovascularization (CNV) compromises corneal avascularity and visual acuity. Current clinical visualization approaches are subjective and unable to provide molecular information. Photoacoustic (PA) imaging offers an objective and non-invasive way for angiogenesis investigation through hemodynamic and oxygen saturation level (sO2) quantification. Here, we demonstrate the utility of PA and slit lamp microscope for in vivo rat CNV model. PA images revealed untreated corneas exhibited higher sO2 level than treatment groups. The PA results complement with the color image obtained with slit lamp. These data suggest PA could offer an objective and non-invasive method for monitoring CNV progression and treatment outcome through the sO2 quantification.
Publisher: Optical Society of America
Journal: Biomedical optics express 
EISSN: 2156-7085
DOI: 10.1364/BOE.423982
Rights: © 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement (
Journal © 2021
© 2021 Optical Society of America. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved.
The following publication Lui, K. H., Li, S., Lo, W. S., Gu, Y., & Wong, W. T. (2021). In vivo photoacoustic imaging for monitoring treatment outcome of corneal neovascularization with metformin eye drops. Biomedical Optics Express, 12(6), 3597-3606 is available at
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