Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/91330
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dc.contributorDepartment of Applied Biology and Chemical Technology-
dc.creatorXie, M-
dc.creatorYang, X-
dc.creatorXu, Q-
dc.creatorYe, L-
dc.creatorChen, K-
dc.creatorZheng, Z-
dc.creatorDong, N-
dc.creatorSun, Q-
dc.creatorShu, L-
dc.creatorGu, D-
dc.creatorChan, EWC-
dc.creatorZhang, R-
dc.creatorChen, S-
dc.date.accessioned2021-11-03T06:52:44Z-
dc.date.available2021-11-03T06:52:44Z-
dc.identifier.urihttp://hdl.handle.net/10397/91330-
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.rights© The Author(s) 2021en_US
dc.rightsOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/.en_US
dc.rightsThe following publication Xie, M., Yang, X., Xu, Q., Ye, L., Chen, K., Zheng, Z., ... & Chen, S. (2021). Clinical evolution of ST11 carbapenem resistant and hypervirulent Klebsiella pneumoniae. Communications biology, 4(1), 1-9 is available at https://doi.org/10.1038/s42003-021-02148-4en_US
dc.titleClinical evolution of ST11 carbapenem resistant and hypervirulent klebsiella pneumoniaeen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.volume4-
dc.identifier.doi10.1038/s42003-021-02148-4-
dcterms.abstractCarbapenem-resistant and hypervirulent K. pneumoniae (CR-HvKP) strains that have emerged recently have caused infections of extremely high mortality in various countries. In this study, we discovered a conjugative plasmid that encodes carbapenem resistance and hypervirulence in a clinical ST86 K2 CR-HvKP, namely 17ZR-91. The conjugative plasmid (p17ZR-91-Vir-KPC) was formed by fusion of a non-conjugative pLVPK-like plasmid and a conjugative blaKPC-2-bearing plasmid and is present dynamically with two other non-fusion plasmids. Conjugation of p17ZR-91-Vir-KPC to other K. pneumoniae enabled them to rapidly express the carbapenem resistance and hypervirulence phenotypes. More importantly, genome analysis provided direct evidence that p17ZR-91-Vir-KPC could be directly transmitted from K2 CR-HvKP strain, 17ZR-91, to ST11 clinical K. pneumoniae strains to convert them into ST11 CR-HvKP strains, which explains the evolutionary mechanisms of recently emerged ST11 CR-HvKP strains.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationCommunications biology, 2021, v. 4, 650-
dcterms.isPartOfCommunications biology-
dcterms.issued2021-
dc.identifier.scopus2-s2.0-85107456029-
dc.identifier.pmid34075192-
dc.identifier.eissn2399-3642-
dc.identifier.artn650-
dc.description.validate202110 bcvc-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_Scopus/WOSen_US
dc.description.pubStatusPublisheden_US
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