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dc.contributorSchool of Nursing-
dc.creatorRan, J-
dc.creatorZhang, Y-
dc.creatorHan, L-
dc.creatorSun, S-
dc.creatorZhao, S-
dc.creatorShen, C-
dc.creatorZhang, X-
dc.creatorChan, KP-
dc.creatorLee, RSY-
dc.creatorQiu, Y-
dc.creatorTian, L-
dc.publisherPergamon Pressen_US
dc.rights© 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (
dc.rightsThe following publication Ran, J., Zhang, Y., Han, L., Sun, S., Zhao, S., Shen, C., ... & Tian, L. (2021). The joint association of physical activity and fine particulate matter exposure with incident dementia in elderly Hong Kong residents. Environment International, 156, 106645 is available at
dc.subjectAlzheimer's diseaseen_US
dc.subjectCohort studyen_US
dc.subjectFine particulate matteren_US
dc.subjectPhysical activityen_US
dc.titleThe joint association of physical activity and fine particulate matter exposure with incident dementia in elderly Hong Kong residentsen_US
dc.typeJournal/Magazine Articleen_US
dcterms.abstractObjective: The evidence for the beneficial effects of physical activity (PA) and potentially detrimental effects of long-term exposure to fine particulate matter (PM2.5) on neurodegeneration diseases is accumulating. However, their joint effects remain unclear. We evaluated joint associations of habitual PA and PM2.5 exposure with incident dementia in a longitudinal elderly cohort in Hong Kong.-
dcterms.abstractMethods: A total of 57,775 elderly participants (≥65 years) without dementia were enrolled during 1998–2001 and followed up till 2011. Their information on PA and other relevant covariates were collected at baseline (1998–2001) by a standard self-administered questionnaire, including PA volumes (high, moderate, low, and inactive) and types (aerobic exercise, traditional Chinese exercise, stretching exercise, walking slowly, and no exercise). Their annual mean PM2.5 exposures at the residential address were estimated using a satellite-based spatiotemporal model. We then adopted the Cox proportional hazards model to examine the joint associations with the incidence of all-cause dementia, Alzheimer's diseases, and vascular dementia on additive and multiplicative scales.-
dcterms.abstractResults: During the follow-up period, we identified 1,157 incident cases of dementia, including 642 cases of Alzheimer's disease and 324 cases of vascular dementia. A higher PA level was associated with a lower risk of incident all-cause dementia (hazard ratio (HR) for the high-PA volume was 0.59 (95% CI, 0.47, 0.75), as compared with the inactive-PA), whereas a high level of PM2.5 was related to the higher risk with an HR of 1.15 (95%CI: 1.00, 1.33) compared with the low-level of PM2.5. No clear evidence was observed of interaction between habitual PA (volume and type) and PM2.5 inhalation to incident dementia on either additive or multiplicative scale.-
dcterms.abstractConclusion: Habitual PA and long-term PM2.5 exposure were oppositely related to incident dementia in the Hong Kong aged population. The benefits of PA remain in people irrespective of exposure to air pollution.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationEnvironment international, Nov. 2021, v. 156, 106645-
dcterms.isPartOfEnvironment international-
dc.description.validate202110 bcvc-
dc.description.oaVersion of Recorden_US
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