Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/91193
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dc.contributorDepartment of Applied Mathematicsen_US
dc.contributorSchool of Nursingen_US
dc.creatorCao, Pen_US
dc.creatorSong, Yen_US
dc.creatorZhuang, Zen_US
dc.creatorRan, Jen_US
dc.creatorXu, Len_US
dc.creatorGeng, Yen_US
dc.creatorHan, Len_US
dc.creatorZhao, Sen_US
dc.creatorQin, Jen_US
dc.creatorHe, Den_US
dc.creatorWu, Fen_US
dc.creatorYang, Len_US
dc.date.accessioned2021-09-17T02:51:20Z-
dc.date.available2021-09-17T02:51:20Z-
dc.identifier.issn0012-1797en_US
dc.identifier.urihttp://hdl.handle.net/10397/91193-
dc.language.isoenen_US
dc.publisherAmerican Diabetes Associationen_US
dc.rights© 2021 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at https://www.diabetesjournals .org/content/license.en_US
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in Diabetes. The final authenticated version is available online at: http://dx.doi.org/10.2337/db20-0671.en_US
dc.titleObesity and COVID-19 in Adult Patients With Diabetesen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage1061en_US
dc.identifier.epage1069en_US
dc.identifier.volume70en_US
dc.identifier.issue5en_US
dc.identifier.doi10.2337/db20-0671en_US
dcterms.abstractObesity has caused wide concerns due to its high prevalence in patients with severe coronavirus disease 2019 (COVID-19). Coexistence of diabetes and obesity could cause an even higher risk of severe outcomes due to immunity dysfunction. We conducted a retrospective study in 1,637 adult patients who were admitted into an acute hospital in Wuhan, China. Propensity score–matched logistic regression was used to estimate the risks of severe pneumonia and requiring in-hospital oxygen therapy associated with obesity. After adjustment for age, sex, and comorbidities, obesity was significantly associated with higher odds of severe pneumonia (odds ratio [OR] 1.47 [95% CI 1.15–1.88]; P = 0.002) and oxygen therapy (OR 1.40 [95% CI 1.10–1.79]; P = 0.007). Higher ORs of severe pneumonia due to obesity were observed in men, older adults, and those with diabetes. Among patients with diabetes, overweight increased the odds of requiring in-hospital oxygen therapy by 0.68 times (P = 0.014) and obesity increased the odds by 1.06 times (P = 0.028). A linear dose-response curve between BMI and severe outcomes was observed in all patients, whereas a U-shaped curve was observed in those with diabetes. Our findings provide important evidence to support obesity as an independent risk factor for severe outcomes of COVID-19 infection in the early phase of the ongoing pandemic.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationDiabetes, May 2021, v. 70, no. 5, p. 1061-1069en_US
dcterms.isPartOfDiabetesen_US
dcterms.issued2021-05-
dc.identifier.isiWOS:000657080800005-
dc.identifier.pmid33597204-
dc.identifier.eissn1939-327Xen_US
dc.description.validate202109 bcwhen_US
dc.description.oaAccepted Manuscripten_US
dc.identifier.FolderNumbera0982-n02-
dc.identifier.SubFormID2260-
dc.description.fundingSourceOthersen_US
dc.description.fundingTextP0031768en_US
dc.description.pubStatusPublisheden_US
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