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Title: Neural and retinal characteristics in relation to working memory in older adults with mild cognitive impairment
Authors: Wong, MNK 
Lai, DWL
Chan, HHL 
Lam, BYH
Issue Date: Mar-2021
Source: Current Alzheimer research, Mar. 2021, v. 18, no. 3, p. 185-195
Abstract: Objective: This study investigated the relationship between neural activities and retinal structures associated with working memory (WM) in older adults with mild cognitive impairment (MCI).
Methods: Eleven older adults with MCI and 29 healthy controls (60 to 73 years old) were tested. All participants underwent an event-related potential (ERP) recording while performing the two-back memory task. The Optical coherence tomography angiography (OCT-A) was administered to examine the perfusion and vessel density in the retina.
Results: Results showed that WM performance in the MCI group was negatively associated with ERP latencies in central parietal regions (CP6 and CP8) (ps< 0.05). The left nasal vessel and perfusion densities were negatively correlated with the latencies in these two central parietal regions and positively related to WM performance only in the MCI group (ps< 0.05).
Conclusion: The findings on WM, central parietal brain activity, and left nasal vessel and perfusion densities in the retina help us gain a better understanding of the neural and retinal underpinnings of WM in relation to MCI.
Keywords: Mild cognitive impairment
Retinal perfusion density
Retinal vessel density
Working memory
Event-related potential
Publisher: Bentham Science Publishers
Journal: Current Alzheimer research 
ISSN: 1567-2050
DOI: 10.2174/1567205018666210608114044
Rights: This is the accepted version of the following article: Mabel N.K. Wong, Daniel W.L. Lai, Henry H.-L. Chan and Bess Y.-H. Lam, “Neural and Retinal Characteristics in Relation to Working Memory in Older Adults with Mild Cognitive Impairment”, Current Alzheimer Research 2021; 18(3). The published manuscript is available at EurekaSelect via
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