Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/91181
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dc.contributorDepartment of Applied Biology and Chemical Technologyen_US
dc.creatorLi, XXen_US
dc.creatorZhang, SJen_US
dc.creatorMan, KYen_US
dc.creatorChiu, APen_US
dc.creatorLo, LHen_US
dc.creatorTo, JCen_US
dc.creatorChiu, CHen_US
dc.creatorChan, COen_US
dc.creatorMok, DKWen_US
dc.creatorRowlands, DKen_US
dc.creatorKeng, VWen_US
dc.date.accessioned2021-09-10T07:22:14Z-
dc.date.available2021-09-10T07:22:14Z-
dc.identifier.issn0006-291Xen_US
dc.identifier.urihttp://hdl.handle.net/10397/91181-
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rights©2020 Elsevier Inc. All rights reserved.en_US
dc.subjectSympathetic nervous systemen_US
dc.subjectSchwann cellen_US
dc.subjectWhite adipose tissueen_US
dc.subjectPtenen_US
dc.titleSchwann cell-specific Pten inactivation reveals essential role of the sympathetic nervous system activity in adipose tissue developmenten_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage118en_US
dc.identifier.epage124en_US
dc.identifier.volume531en_US
dc.identifier.issue2en_US
dc.identifier.doi10.1016/j.bbrc.2020.07.050en_US
dcterms.abstractThere is increasing evidence that the sympathetic nervous system (SNS) plays an important role in adipose tissue development. However, the underlying molecular mechanism(s) associated with this remains unclear. SNS innervation of white adipose tissue (WAT) is believed to be necessary and sufficient to elicit WAT lipolysis. In this current study, mice with Schwann cell (SC)-specific inactivation of phosphatase and tensin homolog (Pten) displayed enlarged inguinal white adipose tissue (iWAT). This serendipitous observation implicates the role of SCs in mediating SNS activity associated with mouse adipose tissue development. Mice with SC-specific Pten inactivation displayed enlarged iWAT. Interestingly, the SNS activity in iWAT of SC-specific Pten-deficient mice was reduced as demonstrated by decreased tyrosine hydroxylase (TH) expression level and neurotransmitters, such as norepinephrine (NE) and histamine (H). The lipolysis related protein, phosphorylated hormone sensitive lipase (pHSL), was also decreased. As expected, AKT-associated signaling pathway was hyperactivated and hypothesized to induce enlarged iWAT in SC-specific Pten-deficient mice. Moreover, preliminary experiments using AKT inhibitor AZD5363 treatment ameliorated the enlarged iWAT condition in SC-specific Pten-deficient mice. Taken together, SCs play an essential role in the regulation of SNS activity in iWAT development via the AKT signaling pathway. This novel role of SCs in SNS function allows for better understanding into the genetic mechanisms of peripheral neuropathy associated obesity.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationBiochemical and biophysical research communications, 15 October 2020, v. 531, no. 2, p. 118-124en_US
dcterms.isPartOfBiochemical and biophysical research communicationsen_US
dcterms.issued2020-10-15-
dc.identifier.isiWOS:000569915900006-
dc.identifier.pmid32782145-
dc.identifier.eissn1090-2104en_US
dc.description.validate202109 bcrcen_US
dc.description.oaAuthor’s Originalen_US
dc.identifier.FolderNumbera0613-n04-
dc.identifier.SubFormID595-
dc.description.fundingSourceRGCen_US
dc.description.fundingTextC5012-15E, R5050-18en_US
dc.description.pubStatusPublisheden_US
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