Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/91044
DC Field | Value | Language |
---|---|---|
dc.contributor | Chinese Mainland Affairs Office | en_US |
dc.contributor | Department of Biomedical Engineering | en_US |
dc.creator | Chen, X | en_US |
dc.creator | Fan, Y | en_US |
dc.creator | Sun, J | en_US |
dc.creator | Zhang, Z | en_US |
dc.creator | Xin, Y | en_US |
dc.creator | Li, K | en_US |
dc.creator | Tang, K | en_US |
dc.creator | Du, P | en_US |
dc.creator | Liu, Y | en_US |
dc.creator | Wang, G | en_US |
dc.creator | Yang, M | en_US |
dc.creator | Tan, Y | en_US |
dc.date.accessioned | 2021-09-09T03:38:28Z | - |
dc.date.available | 2021-09-09T03:38:28Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/91044 | - |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.subject | Cellular stiffness | en_US |
dc.subject | Cancer stem cell | en_US |
dc.subject | Cellular uptake | en_US |
dc.subject | Mechanomedicine | en_US |
dc.subject | Nanoparticle | en_US |
dc.title | Nanoparticle-mediated specific elimination of soft cancer stem cells by targeting low cell stiffness | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 493 | en_US |
dc.identifier.epage | 505 | en_US |
dc.identifier.volume | 135 | en_US |
dc.identifier.doi | 10.1016/j.actbio.2021.08.053 | en_US |
dcterms.abstract | As the driving force of tumor progression, cancer stem cells (CSCs) hold much lower cellular stiffness than bulk tumor cells across many cancer types. However, it remains unclear whether low cell stiffness can be harnessed in nanoparticle-based therapeutics for CSC targeting. We report that breast CSCs exhibit much lower stiffness but considerably higher uptake of nitrogen-doped graphene quantum dots (N-GQDs) than bulk tumor cells. Softening/stiffening cells enhances/suppresses nanoparticle uptake through activating/inhibiting clathrin- and caveolae-mediated endocytosis, suggesting that low cell stiffness mediates the elevated uptake in soft CSCs that may lead to the specific elimination. Further, soft CSCs enhance drug release, cellular retention, and nuclear accumulation of drug-loaded N-GQDs by reducing intracellular pH and exocytosis. Remarkably, drug-loaded N-GQDs specifically eliminate soft CSCs both in vitro and in vivo, inhibit tumor but not animal growth, and reduce the tumorigenicity of xenograft cells. Our findings unveil a new mechanism by which low cellular stiffness can be harnessed in nanoparticle-based strategies for specific CSC elimination, opening a new paradigm of cancer mechanomedicine. | en_US |
dcterms.accessRights | embargoed access | en_US |
dcterms.bibliographicCitation | Acta Biomaterialia, Nov. 2021, v. 135, p. 493-505 | en_US |
dcterms.isPartOf | Acta biomaterialia | en_US |
dcterms.issued | 2021-11 | - |
dc.identifier.eissn | 1742-7061 | en_US |
dc.description.validate | 202109 bchy | en_US |
dc.description.oa | Not applicable | en_US |
dc.identifier.FolderNumber | a1025-n01 | - |
dc.identifier.SubFormID | 2450 | - |
dc.description.fundingSource | RGC | en_US |
dc.description.fundingText | RGC: PolyU 252094/17E, C5011-19G, PolyU 15216917 and 15214619 | en_US |
dc.description.pubStatus | Published | en_US |
dc.date.embargo | 2023-11-30 | en_US |
Appears in Collections: | Journal/Magazine Article |
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