Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/90568
PIRA download icon_1.1View/Download Full Text
DC FieldValueLanguage
dc.contributorDepartment of Health Technology and Informaticsen_US
dc.creatorYang, Xen_US
dc.creatorLiu, Jen_US
dc.creatorWang, Cen_US
dc.creatorCheng, KKYen_US
dc.creatorXu, Hen_US
dc.creatorLi, Qen_US
dc.creatorHua, Ten_US
dc.creatorJiang, Xen_US
dc.creatorSheng, Len_US
dc.creatorMao, Jen_US
dc.creatorLiu, Zen_US
dc.date.accessioned2021-07-28T01:24:14Z-
dc.date.available2021-07-28T01:24:14Z-
dc.identifier.urihttp://hdl.handle.net/10397/90568-
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.rights© The Author(s) 2021 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en_US
dc.rightsThe following publication Yang, X., Liu, J., Wang, C. et al. miR-18a promotes glioblastoma development by down-regulating ALOXE3-mediated ferroptotic and anti-migration activities. Oncogenesis 10(2), 15 (2021) is available at https://doi.org/10.1038/s41389-021-00304-3en_US
dc.titlemiR-18a promotes glioblastoma development by down-regulating ALOXE3-mediated ferroptotic and anti-migration activitiesen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.volume10en_US
dc.identifier.issue2en_US
dc.identifier.doi10.1038/s41389-021-00304-3en_US
dcterms.abstractThe development of glioblastoma (GBM) is typically accompanied by marked changes in lipid metabolism. Oxylipins and their catalyzed enzymes lipoxygenases (LOXs) have been shown to participate in the development of cancers via multiple pathways, while the understanding of LOXs in GBM remains enigmatic. Thus, we aimed to explore the expression and functional roles of LOXs in the development of GBM. Here we showed that ALOXE3 was markedly down-regulated in human GBM. Knockdown of ALOXE3 in GBM cells fostered the orthotopic tumor growth and shortened lifespan in mice. ALOXE3 deficiency rendered GBM cells resistant to p53-SLC7A11 dependent ferroptosis, promoting GBM cell survival. Mechanistically, miR-18a directly targeted ALOXE3 and suppressed its expression and functions in GBM cells. Furthermore, ALOXE3 silencing promoted 12-hydroxyeicosatetraenoic acids (12-HETE) secretion from GBM cells, in turn, 12-HETE enhanced migration of GBM cells by activating Gs-protein-coupled receptor (GsPCR)-PI3K-Akt pathway in an autocrine manner. Altogether, miR-18a/ALOXE3 axis exerts tumor promoting functions by regulating ferroptosis and migration of GBM cells. Targeting miR-18a/ALOXE3 axis may provide novel therapeutic approaches for GBM treatment.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationOncogenesis, 2021, v. 10, no. 2, 15en_US
dcterms.isPartOfOncogenesisen_US
dcterms.issued2021-
dc.identifier.scopus2-s2.0-85100867356-
dc.identifier.eissn2157-9024en_US
dc.identifier.artn15en_US
dc.description.validate202107 bcvcen_US
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumbera0971-n02-
dc.identifier.SubFormID2324-
dc.description.fundingSourceSelf-fundeden_US
dc.description.pubStatusPublisheden_US
Appears in Collections:Journal/Magazine Article
Files in This Item:
File Description SizeFormat 
s41389-021-00304-3.pdf2.36 MBAdobe PDFView/Open
Open Access Information
Status open access
File Version Version of Record
Access
View full-text via PolyU eLinks SFX Query
Show simple item record

Page views

28
Citations as of Jun 26, 2022

Downloads

5
Citations as of Jun 26, 2022

SCOPUSTM   
Citations

12
Citations as of Jun 23, 2022

WEB OF SCIENCETM
Citations

12
Citations as of Jun 23, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.