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Title: Family exposure and the impact of containment measures to children with coronavirus disease 2019 outside Hubei, China : a cross-sectional study
Authors: Yang, S
Feng, X
Du, P
He, D 
Estill, J
Yang, L 
Wen, C
Luo, J
Wang, X
Lu, L
Li, T
Tang, X
Li, W
Xu, H
Liu, E
Cao, P
Chen, Y
Issue Date: Jan-2021
Source: Translational pediatrics, Jan. 2021, v. 10, no. 1, p. 92-102
Abstract: Background: In response to the ongoing epidemic of coronavirus disease 2019 (COVID-19), China has carried out restrictive disease containment measures across the country.
Methods: In this cross-sectional study, we collected demographic and epidemiological data of 376 laboratory-confirmed cases of COVID-19 among children younger than 18 years of age. Using descriptive statistics and odds ratios, we described the odds of exposure outside the family after the implementation of control measures compared to before.
Results: Children diagnosed on or after February 4, 2020, had a lower odds of exposure to COVID-19 outside of the family compared to those diagnosed before February 3, 2020 (OR =0.594, 95% CI: 0.391 to 0.904). In the stratified analysis, children aged 0 to 5 years had the lowest odds of exposure outside of the family (OR =0.420, 95% CI: 0.196 to 0.904) compared to the other age groups assessed.
Conclusions: Our study on the children infected with COVID-19 as well as their exposure within family provided evidence that the implementation of containment measures was effective in reducing the odds of exposure outside of the family, especially for preschool children. Continuation of these efforts, coupled with tailored prevention and health education messaging for younger aged children, may help to reduce the transmission of COVID-19 among children until other therapeutic interventions or vaccines are available.
Keywords: Children
Containment measures
Family exposure
Publisher: AME Publishing Company
Journal: Translational pediatrics 
ISSN: 2224-4336
EISSN: 2224-4344
DOI: 10.21037/tp-20-214
Rights: © Translational Pediatrics.
This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See:
The following publication Yang, S., Feng, X., Du, P., He, D., Estill, J., Yang, L., ... & Chen, Y. (2021). Family exposure and the impact of containment measures to children with coronavirus disease 2019 outside Hubei, China: a cross-sectional study. Translational pediatrics, 10(1), 92-102 is available at
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