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Title: Design, synthesis, biological evaluation and in silico studies of pyrazole‐based NH₂‐acyl oseltamivir analogues as potent neuraminidase inhibitors
Authors: Ye, J 
Lin, L
Xu, J
Chan, PKS
Yang, X
Ma, C 
Issue Date: Apr-2021
Source: Pharmaceuticals, Apr. 2021, v. 14, no. 4, 371
Abstract: Oseltamivir represents one of the most successful neuraminidase (NA) inhibitors in the current anti‐influenza therapy. The 150‐cavity of NA was identified as an additional binding pocket, and novel NA inhibitors have been designed to occupy the 150‐cavity based on the structure information of oseltamivir carboxylate (OC) in complex with NA. In this study, a series of C‐5‐NH2‐acyl derivatives of OC containing the pyrazole moiety were synthesized. Several derivatives exhibited substantial inhibitory activity against NA. Moreover, in silico ADME evaluation indicated that the derivatives were drug‐like with higher oral absorption rates and greater cell permeability than OC. Additionally, molecular docking studies revealed that the derivatives interacted with both the NA enzyme active site and 150‐cavity as expected. The results provided useful information for further structural optimization of OC.
Keywords: 150‐cavity
Influenza virus
Neuraminidase inhibitor
Oseltamivir derivatives
Publisher: MDPI AG
Journal: Pharmaceuticals 
EISSN: 1424-8247
DOI: 10.3390/ph14040371
Rights: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// 4.0/).
The following publication Ye, J., Lin, L., Xu, J., Chan, P. K. S., Yang, X., & Ma, C. (2021). Design, Synthesis, Biological Evaluation and In Silico Studies of Pyrazole-Based NH2-Acyl Oseltamivir Analogues as Potent Neuraminidase Inhibitors. Pharmaceuticals, 14(4), 371 is available at
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