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Title: Low-intensity pulsed ultrasound stimulation for bone fractures healing : a review
Authors: Palanisamy, P 
Alam, M 
Li, S 
Chow, SKH
Zheng, YP 
Issue Date: Mar-2022
Source: Journal of ultrasound in medicine, Mar. 2022, v. 41, no. 3, p. 547-563
Abstract: Low-intensity pulsed ultrasound (LIPUS) is a developing technology, which has been proven to improve fracture healing process with minimal thermal effects. This noninvasive treatment accelerates bone formation through various molecular, biological, and biomechanical interactions with tissues and cells. Although LIPUS treatment has shown beneficial effects on different bone fracture locations, only very few studies have examined its effects on deeper bones. This study provides an overview on therapeutic ultrasound for fractured bones, possible mechanisms of action, clinical evidences, current limitations, and its future prospects.
Keywords: bone healing
delayed unions
fresh fractures
low-intensity pulsed ultrasound
ultrasound therapy
Publisher: American Institute for Ultrasound in Medicine
Journal: Journal of ultrasound in medicine 
ISSN: 0278-4297
EISSN: 1550-9613
DOI: 10.1002/jum.15738
Rights: © 2021 The Authors. Journal of Ultrasound in Medicine published by Wiley Periodicals LLC on behalf of American Institute of Ultrasound in Medicine.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
The following publication Palanisamy, P., Alam, M., Li, S., Chow, S.K.H. and Zheng, Y.-P. (2022), Low-Intensity Pulsed Ultrasound Stimulation for Bone Fractures Healing. J Ultrasound Med, 41: 547-563 is available at
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