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dc.contributorDepartment of Rehabilitation Sciencesen_US
dc.creatorChan, MMYen_US
dc.creatorHan, YMYen_US
dc.publisherSage Publications Ltd.en_US
dc.rights© The Author(s) 2020en_US
dc.rightsCreative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (
dc.rightsThe following publication Chan, M. M., & Han, Y. M. (2020). The Effect of Transcranial Direct Current Stimulation in Changing Resting-State Functional Connectivity in Patients With Neurological Disorders: A Systematic Review. Journal of Central Nervous System Disease 12, 1-15 is available at
dc.subjectTranscranial direct current stimulationen_US
dc.subjectNeurological disordersen_US
dc.subjectResting-state functional connectivityen_US
dc.subjectSystematic reviewen_US
dc.subjectFunctional magnetic resonance imagingen_US
dc.titleThe effect of transcranial direct current stimulation in changing resting-state functional connectivity in patients with neurological disorders : a systematic reviewen_US
dc.typeJournal/Magazine Articleen_US
dcterms.abstractBackground: People with neurological disorders are found to have abnormal resting-state functional connectivity (rsFC), which is associated with the persistent functional impairment found in these patients. Recently, transcranial direct current stimulation (tDCS) has been shown to improve rsFC, although the results are inconsistent.en_US
dcterms.abstractObjective: We hope to explore whether tDCS induces rsFC changes among patients with neurological disorders, whether rsFC is clinically relevant and how different tDCS parameters affect rsFC outcome among these individuals.en_US
dcterms.abstractMethods: A systematic review was conducted according to PRISMA guidelines (systematic review registration number: CRD42020168654). Randomized controlled trials that studied the tDCS effects on rsFC between the experimental and sham-controlled groups using either electrophysiological or neuroimaging methods were included.en_US
dcterms.abstractResults: Active tDCS can induce changes in both localized (ie, brain regions under the transcranial electrodes) and diffused (ie, brain regions not directly influenced by the transcranial electrodes) rsFC. Interestingly, fMRI studies showed that the default mode network was enhanced regardless of patients’ diagnoses, the stimulation paradigms used or the rsFC analytical methods employed. Second, stimulation intensity, but not total stimulation time, appeared to positively influence the effect of tDCS on rsFC.en_US
dcterms.abstractLimitations and conclusion: Due to the inherent heterogeneity in rsFC analytical methods and tDCS protocols, meta-analysis was not conducted. We recommend that future studies may investigate the effect of tDCS on rsFC for repeated cathodal stimulation. For clinicians, we suggest anodal stimulation at a higher stimulation intensity within the safety limit may maximize tDCS effects in modulating aberrant functional connectivity of patients with neurological disorders.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationJournal of central nervous system disease, 1 Jan. 2020, v. 12, p. 1-15en_US
dcterms.isPartOfJournal of central nervous system diseaseen_US
dc.description.validate202104 bcvcen_US
dc.description.oaVersion of Recorden_US
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