Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/89690
DC FieldValueLanguage
dc.contributorDepartment of Biomedical Engineeringen_US
dc.creatorWong, SHDen_US
dc.creatorXu, Xen_US
dc.creatorChen, Xen_US
dc.creatorXin, Yen_US
dc.creatorXu, Len_US
dc.creatorLai, CHNen_US
dc.creatorOh, Jen_US
dc.creatorWong, WKRen_US
dc.creatorWang, Xen_US
dc.creatorHan, Sen_US
dc.creatorYou, Wen_US
dc.creatorShuai, Xen_US
dc.creatorWong, Nen_US
dc.creatorTan, Yen_US
dc.creatorDuan, Len_US
dc.creatorBian, Len_US
dc.date.accessioned2021-04-28T02:29:17Z-
dc.date.available2021-04-28T02:29:17Z-
dc.identifier.issn1530-6984en_US
dc.identifier.urihttp://hdl.handle.net/10397/89690-
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.subjectCancer stem-like cellsen_US
dc.subjectMagnetic actuationen_US
dc.subjectNanoscale tether mobilityen_US
dc.subjectTumor mechanobiologyen_US
dc.subjectLigand presentationen_US
dc.titleManipulation of the nanoscale presentation of integrin ligand produces cancer cells with enhanced stemness and robust tumorigenicityen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage3236en_US
dc.identifier.volume21en_US
dc.identifier.issue7en_US
dc.identifier.doi10.1021/acs.nanolett.1c00501en_US
dcterms.abstractDeveloping strategies for efficient expansion of cancer stem-like cells (CSCs) in vitro will help investigate the mechanism underlying tumorigenesis and cancer recurrence. Herein, we report a dynamic culture substrate tethered with integrin ligand-bearing magnetic nanoparticles via a flexible polymeric linker to enable magnetic manipulation of the nanoscale ligand tether mobility. The cancer cells cultured on the substrate with high ligand tether mobility develop into large semispherical colonies with CSCs features, which can be abrogated by magnetically restricting the ligand tether mobility. Mechanistically, the substrate with high ligand tether mobility suppresses integrin-mediated mechanotransduction and histone-related methylation, thereby enhancing cancer cell stemness. The culture-derived high-stemness cells can generate tumors both locally and at the distant lung and uterus much more efficiently than the low-stemness cells. We believe that this magnetic nanoplatform provides a promising strategy for investigating the dynamic interaction between CSCs and the microenvironment and establishing a cost-effective tumor spheroid model.en_US
dcterms.accessRightsembargoed accessen_US
dcterms.bibliographicCitationNano letters, 14 Apr. 2021, v. 21, no. 7, p. 3225-3236en_US
dcterms.isPartOfNano lettersen_US
dcterms.issued2021-04-14-
dc.identifier.eissn1530-6992en_US
dc.identifier.artn3225en_US
dc.description.validate202104 bcvcen_US
dc.description.oaNot applicableen_US
dc.identifier.FolderNumbera0826-n01en_US
dc.identifier.SubFormID1955-
dc.description.fundingSourceRGCen_US
dc.description.fundingSourceOthersen_US
dc.description.fundingText14205817, 14204618, R4017-18, 252094/17Een_US
dc.description.pubStatusPublisheden_US
dc.date.embargo2022-04-14en_US
Appears in Collections:Journal/Magazine Article
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Embargo End Date 2022-04-14
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