Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/89624
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dc.contributorDepartment of Rehabilitation Sciencesen_US
dc.creatorKannan, Pen_US
dc.creatorCheung, KKen_US
dc.creatorLau, BWMen_US
dc.date.accessioned2021-04-15T07:04:41Z-
dc.date.available2021-04-15T07:04:41Z-
dc.identifier.issn0306-9877en_US
dc.identifier.urihttp://hdl.handle.net/10397/89624-
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.rights© 2018 Elsevier Ltd. All rights reserveden_US
dc.rights©2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.en_US
dc.titleDoes aerobic exercise induced-analgesia occur through hormone and inflammatory cytokine-mediated mechanisms in primary dysmenorrhea?en_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage50en_US
dc.identifier.epage54en_US
dc.identifier.volume123en_US
dc.identifier.doi10.1016/j.mehy.2018.12.011en_US
dcterms.abstractThe popular accepted explanation for the pathogenesis of primary dysmenorrhea is elevated levels of uterine prostaglandins. Aetiological studies report that production of prostaglandins is controlled by the sex hormone progesterone, with prostaglandins and progesterone displaying an inverse relationship (i.e. increased progesterone levels reduce prostaglandin levels). Pro-inflammatory cytokines (interleukin-6 [IL-6] and tumor necrosis factor-alpha [TNF-α]) are also implicated in the pathogenesis of primary dysmenorrhea. High-intensity aerobic exercise is effective for decreasing pain quality and intensity in women with primary dysmenorrhea. However, why and how aerobic exercise is effective for treatment of primary dysmenorrhea remain unclear. Our preliminary non-randomized controlled pilot study to examine the effects of high-intensity aerobic exercise on progesterone, prostaglandin metabolite (13,14-dihydro-15-keto-prostaglandin F2 alpha (KDPGF2α), TNF-α, and pain intensity found increases in progesterone and decreases in KDPGF2α, TNF-α, and pain intensity following high-intensity aerobic exercise relative to no exercise. Given these promising preliminary findings, as well as what is known about the pathogenesis of primary dysmenorrhea, we propose the following scientific hypothesis: high-intensity aerobic exercise utilizes hormone (progesterone) and inflammatory cytokine-mediated mechanisms to reduce the pain associated with primary dysmenorrhea.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationMedical hypotheses, Feb. 2019, v. 123, p. 50-54en_US
dcterms.isPartOfMedical hypothesesen_US
dcterms.issued2019-02-
dc.identifier.isiWOS:000458594400012-
dc.identifier.pmid30696591-
dc.identifier.eissn1532-2777en_US
dc.description.validate202104 bcrcen_US
dc.description.oaAccepted Manuscripten_US
dc.identifier.FolderNumbera0657-n08, a0771-n05-
dc.identifier.SubFormID759, 1548-
dc.description.fundingSourceRGCen_US
dc.description.fundingSourceOthersen_US
dc.description.fundingTextRGC: 1-ZE8G (a0657-n08/759)en_US
dc.description.pubStatusPublisheden_US
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