Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/89573
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dc.contributorInstitute of Textiles and Clothingen_US
dc.contributorUniversity Research Facility in Life Sciencesen_US
dc.creatorPragya, Aen_US
dc.creatorMutalik, Sen_US
dc.creatorYounas, MWen_US
dc.creatorPang, SKen_US
dc.creatorSo, PKen_US
dc.creatorWang, Fen_US
dc.creatorZheng, Zen_US
dc.creatorNoor, Nen_US
dc.date.accessioned2021-04-13T06:08:07Z-
dc.date.available2021-04-13T06:08:07Z-
dc.identifier.urihttp://hdl.handle.net/10397/89573-
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistryen_US
dc.rightsThis journal is © The Royal Society of Chemistry 2021en_US
dc.rightsThis article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License (https://creativecommons.org/licenses/by-nc/3.0/)en_US
dc.titleDynamic cross-linking of an alginate-acrylamide tough hydrogel system : time-resolved in situ mapping of gel self-assemblyen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage10710en_US
dc.identifier.epage10726en_US
dc.identifier.volume11en_US
dc.identifier.issue18en_US
dc.identifier.doi10.1039/d0ra09210jen_US
dcterms.abstractHydrogels are a popular class of biomaterial that are used in a number of commercial applications (e.g.; contact lenses, drug delivery, and prophylactics). Alginate-based tough hydrogel systems, interpenetrated with acrylamide, reportedly form both ionic and covalent cross-links, giving rise to their remarkable mechanical properties. In this work, we explore the nature, onset and extent of such hybrid bonding interactions between the complementary networks in a model double-network alginate-acrylamide system, using a host of characterisation techniques (e.g.; FTIR, Raman, UV-vis, and fluorescence spectroscopies), in a time-resolved manner. Further, due to the similarity of bonding effects across many such complementary, interpenetrating hydrogel networks, the broad bonding interactions and mechanisms observed during gelation in this model system, are thought to be commonly replicated across alginate-based and broader double-network hydrogels, where both physical and chemical bonding effects are present. Analytical techniques followed real-time bond formation, environmental changes and re-organisational processes that occurred. Experiments broadly identified two phases of reaction; phase I where covalent interaction and physical entanglements predominate, and; phase II where ionic cross-linking effects are dominant. Contrary to past reports, ionic cross-linking occurred more favourablyviamannuronate blocks of the alginate chain, initially. Evolution of such bonding interactions was also correlated with the developing tensile and compressive properties. These structure-property findings provide mechanistic insights and future synthetic intervention routes to manipulate the chemo-physico-mechanical properties of dynamically-forming tough hydrogel structures according to need (i.e.; durability, biocompatibility, adhesion,etc.), allowing expansion to a broader range of more physically and/or environmentally demanding biomaterials applications.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationRSC advances, 2021, v. 11, no. 18, p. 10710-10726en_US
dcterms.isPartOfRSC advancesen_US
dcterms.issued2021-
dc.identifier.scopus2-s2.0-85102748927-
dc.identifier.eissn2046-2069en_US
dc.description.validate202104 bcvcen_US
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumbera0710-n01-
dc.identifier.SubFormID1068-
dc.description.fundingSourceRGCen_US
dc.description.fundingSourceOthersen_US
dc.description.fundingTextRGC: UGC-RGC (25303318)en_US
dc.description.fundingTextOthers: Institute of Textiles and Clothing and the Faculty of Applied Sciences and Textiles of The Hong Kong Polytechnic University (1-ZVK4 & 1-ZVLR)en_US
dc.description.pubStatusPublisheden_US
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