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| Title: | Indentation stiffness measurement by an optical coherence tomography-based air-jet indentation system can reflect type I collagen abundance and organisation in diabetic wounds | Authors: | Choi, HMC Cheung, AKK Ng, MCH Zheng, Y Jan, YK Cheing, GLY |
Issue Date: | 4-Mar-2021 | Source: | Frontiers in bioengineering and biotechnology, 4 March 2021, v. 9, 648453 | Abstract: | There is a lack of quantitative and non-invasive clinical biomechanical assessment tools for diabetic foot ulcers. Our previous study reported that the indentation stiffness measured by an optical coherence tomography-based air-jet indentation system in a non-contact and non-invasive manner may reflect the tensile properties of diabetic wounds. As the tensile properties are known to be contributed by type I collagen, this study was aimed to establish the correlations between the indentation stiffness, and type I collagen abundance and organisation, in order to further justify and characterise the in vivo indentation stiffness measurement in diabetic wounds. In a male streptozotocin-induced diabetic rat model, indentation stiffness, and type I collagen abundance and organisation of excisional wounds were quantified and examined using the optical coherence tomography-based air-jet indentation system and picrosirius red polarised light microscopy, respectively, on post-wounding days 3, 5, 7, 10, 14, and 21. The results showed significant negative correlations between indentation stiffness at the wound centre, and the collagen abundance and organisation. The correlations between the indentation stiffness, as well as collagen abundance and organisation of diabetic wounds suggest that the optical coherence tomography-based air-jet indentation system can potentially be used to quantitatively and non-invasively monitor diabetic wound healing in clinical settings, clinical research or preclinical research. | Keywords: | Biomechanical properties Collagen Diabetic wounds Non-invasive measurement Diagnostic device |
Publisher: | Frontiers Media S.A. | Journal: | Frontiers in bioengineering and biotechnology | EISSN: | 2296-4185 | DOI: | 10.3389/fbioe.2021.648453 | Rights: | © 2021 Choi, Cheung, Ng, Zheng, Jan and Cheing. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. The following publication Choi, H. M. C., Cheung, A. K. K., Ng, M. C. H., Zheng, Y., Jan, Y. K., & Cheing, G. L. Y. (2021). Indentation Stiffness Measurement by an Optical Coherence Tomography-Based Air-Jet Indentation System Can Reflect Type I Collagen Abundance and Organisation in Diabetic Wounds. Frontiers in Bioengineering and Biotechnology, 9, 648453 is available at https://doi.org/10.3389/fbioe.2021.648453 |
| Appears in Collections: | Journal/Magazine Article |
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| fbioe-09-648453 (1).pdf | 1.68 MB | Adobe PDF | View/Open |
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