Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/89386
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dc.contributorSchool of Optometryen_US
dc.creatorPan, Fen_US
dc.creatorBanerjee, Sen_US
dc.creatorLuk, KSen_US
dc.creatorTang, CKen_US
dc.creatorYu, SFen_US
dc.date.accessioned2021-03-18T06:32:04Z-
dc.date.available2021-03-18T06:32:04Z-
dc.identifier.issn0146-0404en_US
dc.identifier.urihttp://hdl.handle.net/10397/89386-
dc.description2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018en_US
dc.language.isoenen_US
dc.publisherAssociation for Research in Vision and Ophthalmologyen_US
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.rightsThe following publication Pan, F., Banerjee, S., Luk, K. S., Tang, C. K., & Yu, S. F. (2018). Optical defocus changes signaling of ganglion cells in the mouse retina. Investigative Ophthalmology & Visual Science, 59(9), 706 [Meeting Abstract] is available at https://iovs.arvojournals.org/article.aspx?articleid=2689354.en_US
dc.titleOptical defocus changes signaling of ganglion cells in the mouse retinaen_US
dc.typeConference Paperen_US
dc.identifier.spage1en_US
dc.identifier.volume59en_US
dc.identifier.issue9en_US
dcterms.abstractPurpose : Myopia is a substantial public health problem, affecting 33% of individuals over the age of 12 years in the United States and more than 80% people in Hong Kong. High myopia is a predisposing factor for retinal detachment, myopic retinopathy, and glaucoma, which are leading to loss of vision and blindness. Optical defocus or image blur alters eye growth and refraction. However, optical defocus’s effect on retinal signaling that accounts either for emmetropization or for refractive errors has remained elusive. The research is to determine if the defocus light stimuli or image had effect on signaling of ganglion cells in mouse retina.en_US
dcterms.abstractMethods : ON and OFF alpha ganglion cells were recording from adult C57BL/C57BL:129 wild-type or Kcng4-YFP mice. A white or mono green organic light-emitting display (OLEDXL, Olightek, China; 800 × 600-pixel resolution, 60 Hz refresh rate) was controlled by computer and was presented different spatial frequencies light bar generated by PsychoPy onto the photoreceptor layer. The intensity of the light bar will be above 100 isomerizations (R*)/rod/s in the photopic range.en_US
dcterms.abstractResults : Dark-adapted mouse ganglion cells were recording under different light intensity to find their thresholds and intensity-response profiles. Then defocus the image was projected on the same cell to record these ON and OFF GCs light response with different Len powers. Signal/noise ration decreased with defocus light and image in ON GCs (n=4). OFF GCs (n=5) also had decreased signal/noise ratio with defocus image. Compared with clear and focused light and image, optical defocus image induced more spikes after light off in ON GCs and more spikes in Light on in OFF GCs. Different spatial frequencies can induce different ON and OFF signal/noise ratio.en_US
dcterms.abstractConclusions : Optical defocus changes the signaling of ON and OFF ganglion cell in the mouse retina. The process might be the first step to induce myopia development.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationInvestigative ophthalmology and visual science, July 2018, v. 59, no. 9, 706, p. 1 [Meeting Abstract]en_US
dcterms.isPartOfInvestigative ophthalmology and visual scienceen_US
dcterms.issued2018-07-
dc.relation.conferenceARVO. Annual Meetingen_US
dc.identifier.eissn1552-5783en_US
dc.identifier.artn706en_US
dc.description.validate202103 bcrcen_US
dc.description.oaOther Versionen_US
dc.identifier.FolderNumbera0644-n04en_US
dc.identifier.SubFormID709-
dc.description.fundingSourceOthersen_US
dc.description.fundingTextP0000341, P0000465, P0008663en_US
dc.description.pubStatusPublisheden_US
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