Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/89276
Title: | Chiral cyclometalated oxazoline gold(III) complex-catalyzed asymmetric carboalkoxylation of alkynes | Authors: | Jiang, JJ Cui, JF Yang, B Ning, Y Lai, NCH Wong, MK |
Issue Date: | 6-Aug-2019 | Source: | Organic letters, 6 Aug. 2019, v. 21, no. 16, p. 6289-6294 | Abstract: | Asymmetric catalysis by using novel chiral O,O′-chelated 4,4′-biphenol cyclometalated oxazoline gold(III) complexes has been developed. A high yield (≤89%) and a high enantioselectivity (≤90% ee) were achieved in asymmetric carboalkoxylation of alkynes. Enantioselectivity could be significantly improved from 19% to 90% ee by increasing the steric size of the substituent on the chiral oxazoline ligand. Catalytically active AuIII species and the origin of chiral induction are proposed. | Publisher: | American Chemical Society | Journal: | Organic letters | ISSN: | 1523-7060 | EISSN: | 1523-7052 | DOI: | 10.1021/acs.orglett.9b02171 | Rights: | © 2019 American Chemical Society This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see https://pubs.acs.org/doi/10.1021/acs.orglett.9b02171 |
Appears in Collections: | Journal/Magazine Article |
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File | Description | Size | Format | |
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a0589-n13_Revised Manuscript.pdf | Pre-Published version | 643.16 kB | Adobe PDF | View/Open |
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