Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/89273
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Biology and Chemical Technology | en_US |
dc.creator | Ko, HM | en_US |
dc.creator | Deng, JR | en_US |
dc.creator | Cui, JF | en_US |
dc.creator | Kung, KKY | en_US |
dc.creator | Leung, YC | en_US |
dc.creator | Wong, MK | en_US |
dc.date.accessioned | 2021-03-05T07:39:01Z | - |
dc.date.available | 2021-03-05T07:39:01Z | - |
dc.identifier.issn | 0968-0896 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/89273 | - |
dc.language.iso | en | en_US |
dc.publisher | Pergamon Press | en_US |
dc.rights | © 2020 Elsevier Ltd. All rights reserved | en_US |
dc.rights | © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. | en_US |
dc.rights | The following publication Ko, H.-M., Deng, J.-R., Cui, J.-F., Kung, K. K.-Y., Leung, Y.-C., & Wong, M.-K. (2020). Selective modification of alkyne-linked peptides and proteins by cyclometalated gold(III) (C^N) complex-mediated alkynylation. Bioorganic & Medicinal Chemistry, 28(7), 115375 is available at https://dx.doi.org/10.1016/j.bmc.2020.115375. | en_US |
dc.subject | Alkynylation | en_US |
dc.subject | Bioconjugation reaction | en_US |
dc.subject | Gold complexes | en_US |
dc.subject | Protein modification | en_US |
dc.title | Selective modification of alkyne-linked peptides and proteins by cyclometalated gold(III) (C^N) complex-mediated alkynylation | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 28 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.doi | 10.1016/j.bmc.2020.115375 | en_US |
dcterms.abstract | Alkyne is a useful functionality incorporated in proteins for site-selective bioconjugation reactions. Although effective bioconjugation reactions such as copper(I)-catalyzed and/or copper-free 1,3-dipolar cycloadditions of alkynes and azides are the most common approaches, the development of new alkyne-based bioconjugation reactions is still an ongoing interest in chemical biology. In this work, a new approach has been developed for selective modification of alkyne-linked peptides and proteins through the formation of arylacetylenes by a cross-coupling reaction of 6-membered ring cyclometalated gold(III) (C^N) complexes (HC^N = 2-arylpyridines) with terminal alkynes. Screening of the reaction conditions with a series of cyclometalated gold(III) complexes with phenylacetylene gave an excellent yield (up to 82%) by conducting the reaction in slightly alkaline aqueous conditions. The reaction scope was expanded to various alkynes, including alkyne-linked peptides to achieve up to >99% conversion. Using fluorescent dansyl (1l) and BODIPY (1m)-linked gold(III) complexes, alkyne-linked lysozyme has been selectively modified. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Bioorganic & medicinal chemistry, 1 Apr. 2020, v. 28, no. 7, 115375 | en_US |
dcterms.isPartOf | Bioorganic & medicinal chemistry | en_US |
dcterms.issued | 2020-04-01 | - |
dc.identifier.scopus | 2-s2.0-85080024469 | - |
dc.identifier.pmid | 32122753 | - |
dc.identifier.eissn | 1464-3391 | en_US |
dc.identifier.artn | 115375 | en_US |
dc.description.validate | 202103 bcvc | en_US |
dc.description.oa | Accepted Manuscript | en_US |
dc.identifier.FolderNumber | a0589-n03 | - |
dc.identifier.SubFormID | 310 | - |
dc.description.fundingSource | RGC | en_US |
dc.description.fundingText | PolyU 5031/11P | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Ko_Modification_Alkyne-linked_Peptides.pdf | Pre-Published version | 1.18 MB | Adobe PDF | View/Open |
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