Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/89269
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dc.contributorDepartment of Biomedical Engineeringen_US
dc.creatorLv, Sen_US
dc.creatorNie, Jen_US
dc.creatorGao, Qen_US
dc.creatorXie, Cen_US
dc.creatorZhou, Len_US
dc.creatorQiu, Jen_US
dc.creatorFu, Jen_US
dc.creatorZhao Xen_US
dc.creatorHe, Yongen_US
dc.date.accessioned2021-03-04T04:01:14Z-
dc.date.available2021-03-04T04:01:14Z-
dc.identifier.issn1758-5082en_US
dc.identifier.urihttp://hdl.handle.net/10397/89269-
dc.language.isoenen_US
dc.publisherInstitute of Physics Publishingen_US
dc.rights© 2020 IOP Publishing Ltd.en US
dc.rightsThis is the Accepted Manuscript version of an article accepted for publication in Biofabrication. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://dx.doi.org/10.1088/1758-5090/ab57d8.en US
dc.subjectHydrogel micro/nanofabricationen_US
dc.subjectUltrafine fiber molden_US
dc.subjectDamage-free demoldingen_US
dc.subjectMicro/nano 3D printingen_US
dc.subjectElectrohydrodynamic printingen_US
dc.subjectHydrogel bio-microfluidic chipen_US
dc.subjectCell patternsen_US
dc.titleMicro/nanofabrication of brittle hydrogels using 3D printed soft ultrafine fiber molds for damage-free demoldingen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.volume12en_US
dc.identifier.issue2en_US
dc.identifier.doi10.1088/1758-5090/ab57d8en_US
dcterms.abstractHydrogels are very popular in biomedical areas for their extraordinary biocompatibility. However, most bio-hydrogels are too brittle to perform micro/nanofabrication. An effective method is cast molding; yet during this process, many defects occur as the excessive demolding stress damages the brittle hydrogels. Here, we propose a brand-new damage-free demolding method and a soft ultrafine fiber mold (SUFM) to replace the traditional mold. Both mechanical and finite element analysis (FEA) reveal that SUFMs have obvious advantages especially when the contact area between hydrogel and mold gets larger. By means of a high-resolution 3D printing called electrohydrodynamic (EHD) printing, SUFMs with various topological structures can be achieved with the fiber diameter ranging from 500 nm to 100 μm, at a low cost. Microfluidics and cell patterns are implemented as the demonstration for potential applications. Owing to the tiny scale of microstructures and the hydrophilicity of hydrogels, significant capillary effect occurs which can be utilized to deliver liquid and cells autonomously and to seed cells into those ultrafine channels evenly. The results open up a new avenue for a wider use of hydrogels in biomedical devices, tissue engineering, hydrogel-based microfluidics and wearable electronics; the proposed fabrication method also has the potential to become a universal technique for micro/nanofabrication of brittle materials.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationBiofabrication, Apr. 2020, v. 12, no. 2, 025015en_US
dcterms.isPartOfBiofabricationen_US
dcterms.issued2020-04-
dc.identifier.eissn1758-5090en_US
dc.identifier.artn025015en_US
dc.description.validate202103 bcrcen_US
dc.description.oaAccepted Manuscripten_US
dc.identifier.FolderNumbera0596-n29-
dc.identifier.SubFormID469-
dc.description.fundingSourceSelf-fundeden_US
dc.description.pubStatusPublisheden_US
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