Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/89268
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dc.contributorDepartment of Biomedical Engineeringen_US
dc.creatorWang, XTen_US
dc.creatorLiu, XPen_US
dc.creatorZhu, HDen_US
dc.creatorZhang, GWen_US
dc.creatorLi, XFen_US
dc.creatorTang, CYen_US
dc.creatorLaw, WCen_US
dc.creatorZhao, Xen_US
dc.date.accessioned2021-03-03T09:20:48Z-
dc.date.available2021-03-03T09:20:48Z-
dc.identifier.issn0142-9418en_US
dc.identifier.urihttp://hdl.handle.net/10397/89268-
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rights© 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)en_US
dc.rightsThe following publication Wang, X., Liu, X., Zhu, H., Zhang, G., Li, X., Tang, C. Y., ... & Zhao, X. (2021). Near infrared to ultraviolet upconversion nanocomposite for controlling the permittivity of polyspiropyran shell. Polymer Testing, 94, 107042, 1-10 is available at https://doi.org/10.1016/j.polymertesting.2020.107042.en_US
dc.subjectUp-conversion nanoparticleen_US
dc.subjectDual-responsiveen_US
dc.subjectControlled drug releaseen_US
dc.subjectNanocompositeen_US
dc.titleNear infrared to ultraviolet upconversion nanocomposite for controlling the permittivity of polyspiropyran shellen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage1en_US
dc.identifier.epage10en_US
dc.identifier.volume94en_US
dc.identifier.doi10.1016/j.polymertesting.2020.107042en_US
dcterms.abstractNear infrared to ultraviolet (NIR-to-UV) up-conversion nanocomposites, composed of an upconversion nanoparticle (UCNP) core and a transformable polyspiropyran shell, were prepared by distillation precipitation polymerization and the template method. The polyspiropyran shell can undergo reversible hydrophoblic-hydrophilic transformations through the switching of UV and visible light and by variation of pH. About 10 wt% of the anticancer drug, doxorubicin (DOX), can be loaded into the drug carrying layer under pH 7.4 by electrostatic force. The NIR and pH responsive features of the polyspiropyran shell were shown by the dynamic light scattering (DLS) results, in which the size of nanocomposites (UCNPs@SP-MA/MAA) became larger under NIR irradiation and pH 4.5. The hydrophobic to hydrophilic surface transformation alters the permittivity of the polyspiropyran shell and the release behavior. The cumulative release rate of the DOX-loaded UCNPs@SP-MA/MAA reached 53.8% under pH 4.5 and NIR irradiation. The cytotoxicity of the bare UCNPs@SP-MA/MAA and the DOX-loaded UCNPs@SP-MA/MAA were evaluated against breast cancer cells and the results confirmed that the toxicity of UCNPs@SP-MA/MAA nanocomposites was minimal, even at high dosage (100 μg/mL), while the toxicity of DOX can be triggered by NIR light.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationPolymer testing, Feb. 2021, v. 94, 107042, p. 1-10en_US
dcterms.isPartOfPolymer testingen_US
dcterms.issued2021-02-
dc.identifier.artn107042en_US
dc.description.validate202103 bcrcen_US
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumbera0596-n21-
dc.identifier.SubFormID439-
dc.description.fundingSourceRGCen_US
dc.description.fundingText15202119en_US
dc.description.pubStatusPublisheden_US
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