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http://hdl.handle.net/10397/88483
Title: | Mesenchymal transformation : the rosetta stone of glioblastoma pathogenesis and therapy resistance | Authors: | Azam, Z To, SST Tannous, BA |
Issue Date: | 2020 | Source: | Advanced science, 2020, 2002015, p. 1-13 | Abstract: | Despite decades of research, glioblastoma (GBM) remains invariably fatal among all forms of cancers. The high level of inter- and intratumoral heterogeneity along with its biological location, the brain, are major barriers against effective treatment. Molecular and single cell analysis identifies different molecular subtypes with varying prognosis, while multiple subtypes can reside in the same tumor. Cellular plasticity among different subtypes in response to therapies or during recurrence adds another hurdle in the treatment of GBM. This phenotypic shift is induced and sustained by activation of several pathways within the tumor itself, or microenvironmental factors. In this review, the dynamic nature of cellular shifts in GBM and how the tumor (immune) microenvironment shapes this process leading to therapeutic resistance, while highlighting emerging tools and approaches to study this dynamic double-edged sword are discussed. | Keywords: | Clinical outcome Glioblastoma (GBM) Mesenchymal transition Molecular subtypes Therapy responses Tumor microenvironment |
Publisher: | Wiley-VCH | Journal: | Advanced science | ISSN: | 2198-3844 | DOI: | 10.1002/advs.202002015 | Rights: | © 2020 The Authors. Published by Wiley‐VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. The following publication Azam, Z., To, S. S. T., & Tannous, B. A. (2020). Mesenchymal Transformation: The Rosetta Stone of Glioblastoma Pathogenesis and Therapy Resistance. Advanced Science, 2002015, 1-13 is available at https://dx.doi.org/10.1002/advs.202002015 |
Appears in Collections: | Journal/Magazine Article |
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Azam_Mesenchymal_Transformation_Rosetta.pdf | 2.11 MB | Adobe PDF | View/Open |
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