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Title: New applications of oleanolic acid and its derivatives as cardioprotective agents : a review of their therapeutic perspectives
Authors: Sun, N 
Li, D
Chen, X
Wu, P
Lu, YJ
Hou, N
Chen, WH
Wong, WL 
Issue Date: 2019
Source: Current pharmaceutical design, 2019, v. 25, no. 35, p. 3740-3750
Abstract: Oleanolic acid is an analogue of pentacyclic triterpenoids. It has been used as a hepatic drug for over 20 years in China. Currently, there are only five approved drugs derived from pentacyclic triterpenoids, including oleanolic acid (liver diseases), asiaticoside (wound healing), glycyrrhizinate (liver diseases), isoglycyrrhizinate (liver disease) and sodium aescinate (hydrocephalus). To understand more about the bioactivity and functional mechanisms of oleanolic acid, it can be developed as a potent therapeutic agent, in particular, for the prevention and treatment of heart diseases that are the leading cause of death for people worldwide. The primary aim of this mini-review is to summarize the new applications of oleanolic acid and its derivatives as cardioprotective agents reported in recent years and to highlight their therapeutic perspectives in cardiovascular diseases.
Keywords: Asiaticoside
Cardioprotective agents
Cardiovascular diseases
Hepatic drug
Oleanolic acid
Pentacyclic triterpenoids
Publisher: Bentham Science Publishers
Journal: Current pharmaceutical design 
ISSN: 1381-6128
DOI: 10.2174/1381612825666191105112802
Rights: © Bentham Science Publishers
Ning Sun , Dongli Li , Xiaoqing Chen, Panpan Wu , Yu-Jing Lu , Ning Hou, Wen-Hua Chen and Wing-Leung Wong, “New Applications of Oleanolic Acid and its Derivatives as Cardioprotective Agents: A Review of their Therapeutic Perspectives”, Current Pharmaceutical Design (2019) 25: 3740||The published manuscript is available at EurekaSelect via
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