Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/88366
DC Field | Value | Language |
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dc.contributor | Institute of Textiles and Clothing | - |
dc.creator | Ji, Y | - |
dc.creator | Liu, X | - |
dc.creator | Li, J | - |
dc.creator | Xie, X | - |
dc.creator | Huang, M | - |
dc.creator | Jiang, J | - |
dc.creator | Liao, YP | - |
dc.creator | Donahue, T | - |
dc.creator | Meng, H | - |
dc.date.accessioned | 2020-10-29T01:02:44Z | - |
dc.date.available | 2020-10-29T01:02:44Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/88366 | - |
dc.language.iso | en | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.rights | © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | en_US |
dc.rights | The following publication Ji, Y., Liu, X., Li, J. et al. Use of ratiometrically designed nanocarrier targeting CDK4/6 and autophagy pathways for effective pancreatic cancer treatment. Nat Commun 11, 4249 (2020), is available at https://doi.org/10.1038/s41467-020-17996-7 | en_US |
dc.title | Use of ratiometrically designed nanocarrier targeting CDK4/6 and autophagy pathways for effective pancreatic cancer treatment | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 11 | - |
dc.identifier.issue | 1 | - |
dc.identifier.doi | 10.1038/s41467-020-17996-7 | - |
dcterms.abstract | Aberrant cell cycle machinery and loss of the CDKN2A tumor suppressor locus make CDK4/6 a potential target in pancreatic ductal adenocarcinoma (PDAC). However, a vast majority of PDAC cases do not harbor a durable response to monotherapy of CDK4/6 inhibitor. Utilizing remote loading to co-encapsulate CDK4/6 inhibitor palbociclib (PAL) and an autophagy inhibitor hydroxychloroquine (HCQ), we demonstrate a ratiometrically designed mesoporous silica nanoformulation with synergistic efficacy in subcutaneous and orthotopic PDAC mouse models. The synergism is attributed to the effective intratumoral buildup of PAL/HCQ, which otherwise exhibit distinctly different circulatory and biodistribution profile. PAL/HCQ co-delivery nanoparticles lead to the most effective shrinkage of PDAC compared to various controls, including free drug mixture. Immunohistochemistry reveals that PAL/HCQ co-delivery nanoparticles trigger anti-apoptotic pathway after repetitive intravenous administrations in mice. When combined with a Bcl inhibitor, the performance of co-delivery nanoparticles is further improved, leading to a long-lasting anti-PDAC effect in vivo. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Nature communications, 2020, v. 11, no. 1, 4249 | - |
dcterms.isPartOf | Nature communications | - |
dcterms.issued | 2020 | - |
dc.identifier.scopus | 2-s2.0-85089907143 | - |
dc.identifier.pmid | 32843618 | - |
dc.identifier.eissn | 2041-1723 | - |
dc.identifier.artn | 4249 | - |
dc.description.validate | 202010 bcma | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
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Ji_Use_ratiometrically_designed.pdf | 4.78 MB | Adobe PDF | View/Open |
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