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Title: | DNA nanotechnology as a tool to develop molecular tension probes for bio-sensing and bio-imaging applications : an up-to-date review | Authors: | Baig, MMFA Lai, WF Akhtar, MF Saleem, A Ahmed, SA Xia, XH |
Issue Date: | 2020 | Source: | Nano-Structures & Nano-Objects, 2020, v. 23, 100523 | Abstract: | DNA is known to be a life material that has been explored as an exciting biomaterial for bio-sensing, bio-imaging, and analytical applications. The current review focuses on describing the general concept of DNA nanotechnology including linear DNA nanotechnology, short circular DNA nanotechnology, DNA origami, and the hybrid protein–DNA nanotechnology/supramolecular approaches. We will further describe the existing strategies for the development of DNA molecular tension probes to target the cell surface receptors (mainly integrin) for bio-imaging and bio-sensing applications. The surface activation of the cellular receptors by the DNA probes will elicit the mechanical responses to the cells for the analysis and bio-imaging of mechano-biological processes. The literature overview is obvious about the role of cell surface receptors in generating piconewton (pN) forces and carrying out mechano-transduction events necessary for the growth, development, and proper functioning of the cells. The last part of the review will briefly summarize our contribution as a latest advancement in this field, and to establish a further need for research. | Keywords: | Bio-imaging Bio-sensing DNA (Deoxyribose nucleic acids) Mechano-transduction Piconewton (pN) forces |
Publisher: | Elsevier BV | Journal: | Nano-Structures & Nano-Objects | ISSN: | 2352-507X | EISSN: | 2352-5088 | DOI: | 10.1016/j.nanoso.2020.100523 | Rights: | © 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). The following publication Baig, M. M. F. A., Lai, W. F., Akhtar, M. F., Saleem, A., Ahmed, S. A., & Xia, X. H. (2020). DNA nanotechnology as a tool to develop molecular tension probes for bio-sensing and bio-imaging applications: An up-to-date review. Nano-Structures & Nano-Objects, 23, 100523, is available at https://doi.org/10.1016/j.nanoso.2020.100523 |
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