Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/88309
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dc.contributorDepartment of Applied Biology and Chemical Technologyen_US
dc.creatorChan, SYen_US
dc.creatorLiu, SYen_US
dc.creatorSeng, Zen_US
dc.creatorChua, SLen_US
dc.date.accessioned2020-10-27T09:18:51Z-
dc.date.available2020-10-27T09:18:51Z-
dc.identifier.issn1751-7362en_US
dc.identifier.urihttp://hdl.handle.net/10397/88309-
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.rights© The Author(s), under exclusive licence to International Society for Microbial Ecology 2020en_US
dc.rightsThis version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use (https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms), but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1038/s41396-020-00779-9.en_US
dc.subjectBiofilmen_US
dc.subjectPseudomonas aeruginosaen_US
dc.subjectCaenorhabditis elegansen_US
dc.subjectc-di-GMPen_US
dc.subjectBiofilm matrixen_US
dc.titleBiofilm matrix disrupts nematode motility and predatory behavioren_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage260en_US
dc.identifier.epage269en_US
dc.identifier.issue15en_US
dc.identifier.doi10.1038/s41396-020-00779-9en_US
dcterms.abstractIn nature, bacteria form biofilms by producing exopolymeric matrix that encase its entire community. While it is widely known that biofilm matrix can prevent bacterivore predation and contain virulence factors for killing predators, it is unclear if they can alter predator motility. Here, we report a novel ‘quagmire’ phenotype, where Pseudomonas aeruginosa biofilms could retard the motility of bacterivorous nematode Caenorhabditis elegans via the production of a specific exopolysaccharide, Psl. Psl could reduce the roaming ability of C. elegans by impeding the slithering velocity of C. elegans. Furthermore, presence of Psl in biofilms could entrap C. elegans within the matrix, with dire consequences to the nematode. After being trapped in biofilms, C. elegans could neither escape effectively from aversive stimuli (noxious blue light), nor leave easily to graze on susceptible biofilm areas. Hence, this reduced the ability of C. elegans to roam and predate on biofilms. Taken together, our work reveals a new function of motility interference by specific biofilm matrix components, and emphasizes its importance in predator-prey interactions.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationISME journal, Jan 2021, v. 15, p. 260-269en_US
dcterms.isPartOfISME journalen_US
dcterms.issued2021-01-
dc.identifier.eissn1751-7370en_US
dc.description.validate202010 bcrcen_US
dc.description.oaAccepted Manuscripten_US
dc.identifier.FolderNumbera0491-n03-
dc.description.pubStatusPublisheden_US
Appears in Collections:Journal/Magazine Article
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