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Title: Conformational manipulation of scale-up prepared single-chain polymeric nanogels for multiscale regulation of cells
Authors: Chen, X
Li, R
Wong, SHD 
Wei, K
Cui, M
Chen, H
Jiang, Y 
Yang, B
Zhao, P
Xu, J
Chen, H
Yin, C
Lin, S
Lee, WYW
Jing, Y
Li, Z
Yang, Z
Xia, J
Chen, G
Li, G
Bian, L
Issue Date: 2019
Source: Nature communications, 2019, v. 10, no. 1, 2705, p. 1-12
Abstract: Folded single chain polymeric nano-objects are the molecular level soft material with ultra-small size. Here, we report an easy and scalable method for preparing single-chain nanogels (SCNGs) with improved efficiency. We further investigate the impact of the dynamic molecular conformational change of SCNGs on cellular interactions from molecular to bulk scale. First, the supramolecular unfoldable SCNGs efficiently deliver siRNAs into stem cells as a molecular drug carrier in a conformation-dependent manner. Furthermore, the conformation changes of SCNGs enable dynamic and precise manipulation of ligand tether structure on 2D biomaterial interfaces to regulate the ligand–receptor ligation and mechanosensing of cells. Lastly, the dynamic SCNGs as the building blocks provide effective energy dissipation to bulk biomaterials such as hydrogels, thereby protecting the encapsulated stem cells from deleterious mechanical shocks in 3D matrix. Such a bottom-up molecular tailoring strategy will inspire further applications of single-chain nano-objects in the biomedical area.
Publisher: Nature Publishing Group
Journal: Nature communications 
EISSN: 2041-1723
DOI: 10.1038/s41467-019-10640-z
Rights: Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
© The Author(s) 2019
The following publication Chen, X., Li, R., Wong, S. et al. Conformational manipulation of scale-up prepared single-chain polymeric nanogels for multiscale regulation of cells. Nat Commun 10, 2705 (2019) is available at
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