Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/88146
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dc.contributorDepartment of Health Technology and Informatics-
dc.contributorDepartment of Rehabilitation Sciences-
dc.creatorWang, PJen_US
dc.creatorLiang, YYen_US
dc.creatorChen, Ken_US
dc.creatorYau, SYen_US
dc.creatorSun, Xen_US
dc.creatorCheng, KNYen_US
dc.creatorXu, AMen_US
dc.creatorSo, WAen_US
dc.creatorLi, Aen_US
dc.date.accessioned2020-09-18T02:13:12Z-
dc.date.available2020-09-18T02:13:12Z-
dc.identifier.urihttp://hdl.handle.net/10397/88146-
dc.language.isoenen_US
dc.publisherFrontiers Research Foundationen_US
dc.rights© 2020 Wang, Liang, Chen, Yau, Sun, Cheng, Xu, So and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.rightsThe following publication Wang, P. J., Liang, Y. Y., Chen, K., Yau, S. Y., Sun, X., Cheng, K. NY., . . . Li, A. (2020). Potential involvement of adiponectin signaling in regulating physical exercise-elicited hippocampal neurogenesis and dendritic morphology in stressed mice. Frontiers in Cellular Neuroscience, 14, 1-24 is available at https://dx.doi.org/10.3389/fncel.2020.00189en_US
dc.subjectDepressionen_US
dc.subjectVoluntary exerciseen_US
dc.subjectAdiponectinen_US
dc.subjectDentate gyrusen_US
dc.subjectHippocampal neurogenesisen_US
dc.subjectDendritic plasticityen_US
dc.titlePotential involvement of adiponectin signaling in regulating physical exercise-elicited hippocampal neurogenesis and dendritic morphology in stressed miceen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage1en_US
dc.identifier.epage24en_US
dc.identifier.volume14en_US
dc.identifier.doi10.3389/fncel.2020.00189en_US
dcterms.abstractAdiponectin, a cytokine secreted by mature adipocytes, proves to be neuroprotective. We have previously reported that running triggers adiponectin up-regulation which subsequently promotes generation of hippocampal neurons and thereby alleviates depression-like behaviors in non-stressed mice. However, under the stressing condition, whether adiponectin could still exert antidepressant-like effects following exercise remained unexplored. In this study, by means of repeated corticosterone injections to mimic stress insult and voluntary wheel running as physical exercise intervention, we examined whether exercise-elicited antidepressive effects might involve adiponectin's regulation on hippocampal neurogenesis and dendritic plasticity in stressed mice. Here we show that repeated injections of corticosterone inhibited hippocampal neurogenesis and impaired dendritic morphology of neurons in the dentate gyrus of both wild-type and adiponectin-knockout mice comparably, which subsequently evoked depression-like behaviors. Voluntary wheel running attenuated corticosterone-suppressed neurogenesis and enhanced dendritic plasticity in the hippocampus, ultimately reducing depression-like behaviors in wild-type, but not adiponectin-knockout mice. We further demonstrate that such proneurogenic effects were potentially achieved through activation of the AMP-dependent kinase (AMPK) pathway. Our study provides the first evidence that adiponectin signaling is essential for physical exercise-triggered effects on stress-elicited depression by retaining the normal proliferation of neural progenitors and dendritic morphology of neurons in the hippocampal dentate gyrus, which may depend on activation of the AMPK pathway.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationFrontiers in cellular neuroscience, 3 July 2020, v. 14, 189, p. 1-24en_US
dcterms.isPartOfFrontiers in cellular neuroscienceen_US
dcterms.issued2020-07-03-
dc.identifier.isiWOS:000553933100001-
dc.identifier.pmid32774242-
dc.identifier.eissn1662-5102en_US
dc.identifier.artn189en_US
dc.description.validate202009 bcrc-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumbera0763-n07, OA_Scopus/WOSen_US
dc.identifier.SubFormID1500en_US
dc.description.fundingSourceSelf-fundeden_US
dc.description.pubStatusPublisheden_US
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