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http://hdl.handle.net/10397/88124
Title: | Nitric oxide-producing cardiovascular stent coatings for prevention of thrombosis and restenosis | Authors: | Rao, JD Bei, HP Yang, YH Liu, Y Lin, HD Zhao, X |
Issue Date: | Jun-2020 | Source: | Frontiers in bioengineering and biotechnology, June 2020, v. 8, 578, p. 1-10 | Abstract: | Cardiovascular stenting is an effective method for treating cardiovascular diseases (CVDs), yet thrombosis and restenosis are the two major clinical complications that often lead to device failure. Nitric oxide (NO) has been proposed as a promising small molecule in improving the clinical performance of cardiovascular stents thanks to its anti-thrombosis and anti-restenosis ability, but its short half-life limits the full use of NO. To produce NO at lesion site with sufficient amount, NO-producing coatings (including NO-releasing and NO-generating coatings) are fashioned. Its releasing strategy is achieved by introducing exogenous NO storage materials like NO donors, while the generating strategy utilizes thein vivosubstances such asS-nitrosothiols (RSNOs) to generate NO flux. NO-producing stents are particularly promising in future clinical use due to their ability to store NO resources or to generate large NO flux in a controlled and efficient manner. In this review, we first introduce NO-releasing and -generating coatings for prevention of thrombosis and restenosis. We then discuss the advantages and drawbacks on releasing and generating aspects, where possible further developments are suggested. | Keywords: | Cardiovascular stents Surface coating Nitric oxide Restenosis Thrombosis |
Publisher: | Frontiers Media SA | Journal: | Frontiers in bioengineering and biotechnology | EISSN: | 2296-4185 | DOI: | 10.3389/fbioe.2020.00578 | Rights: | © 2020 Rao, Pan Bei, Yang, Liu, Lin and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. The following publication Rao, J. D., Bei, H. P., Yang, Y. H., Liu, Y., Lin, H. D., & Zhao, X. (2020). Nitric oxide-producing cardiovascular stent coatings for prevention of thrombosis and restenosis. Frontiers in Bioengineering and Biotechnology, 8, 1-10 is available at https://dx.doi.org/10.3389/fbioe.2020.00578 |
Appears in Collections: | Journal/Magazine Article |
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Rao_Nitric_Oxide-Producing_Cardiovascular.pdf | 1.1 MB | Adobe PDF | View/Open |
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