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http://hdl.handle.net/10397/88121
Title: | Targeted neurostimulation in mouse brains with non-invasive ultrasound | Authors: | Qiu, ZH Kala, S Guo, JH Xian, QX Zhu, JJ Zhu, T Hou, XD Wong, KF Yang, MY Wang, HR Sun, L |
Issue Date: | 18-Aug-2020 | Source: | Cell reports, 18 Aug. 2020, v. 32, no. 7, 108033, p. 1-15 | Abstract: | Recently developed brain stimulation techniques have significantly advanced our ability to manipulate the brain's function. However, stimulating specific neurons in a desired region without significant surgical invasion remains a challenge. Here, we demonstrate a neuron-specific and region-targeted neural excitation strategy using non-invasive ultrasound through activation of heterologously expressed mechanosensitive ion channels (MscL-G22S). Low-intensity ultrasound is significantly better at inducing Ca2+ influx and neuron activation in vitro and at evoking electromyogram (EMG) responses in vivo in targeted cells expressing MscL-G22S. Neurons in the cerebral cortex or dorsomedial striatum of mice are made to express MscL-G22S and stimulated ultrasonically. We find significant upregulation of c-Fos in neuron nuclei only in the regions expressing MscL-G22S compared with the non-MscL controls, as well as in various other regions in the same brain. Thus, we detail an effective approach for activating specific regions and cell types in intact mouse brains by sensitizing them to ultrasound using a mechanosensitive ion channel. | Publisher: | Cell Press | Journal: | Cell reports | EISSN: | 2211-1247 | DOI: | 10.1016/j.celrep.2020.108033 | Description: | Correction appeared in: Qiu, Z., Kala, S., Guo, J., Xian, Q., Zhu, J., Zhu, T., ... & Sun, L. (2021). Correction: Targeted neurostimulation in mouse brains with non-invasive ultrasound. Cell Reports, 34(1), 108595 https://doi.org/10.1016/j.celrep.2020.108595 https://ira.lib.polyu.edu.hk/handle/10397/94308 |
Rights: | © 2020 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) The following publication Qiu, Z. H., Kala, S., Guo, J. H., Xian, Q. X., Zhu, J. J., Zhu, T., . . . Sun, L. (2020). Targeted neurostimulation in mouse brains with non-invasive ultrasound. Cell Reports, 32(7), 1-15 is available at https://dx.doi.org/10.1016/j.celrep.2020.108033 |
Appears in Collections: | Journal/Magazine Article |
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