Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/87817
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Health Technology and Informatics | - |
dc.creator | Tam, SY | - |
dc.creator | Wu, VWC | - |
dc.creator | Law, HKW | - |
dc.date.accessioned | 2020-08-19T06:27:26Z | - |
dc.date.available | 2020-08-19T06:27:26Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/87817 | - |
dc.language.iso | en | en_US |
dc.publisher | Frontiers Research Foundation | en_US |
dc.rights | © 2020 Tam, Wu and Law. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)(https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | en_US |
dc.rights | The following publication Tam SY, Wu VWC and Law HKW (2020) Hypoxia-Induced Epithelial-Mesenchymal Transition in Cancers: HIF-1α and Beyond. Front. Oncol. 10:486 is available at https://dx.doi.org/10.3389/fonc.2020.00486 | en_US |
dc.subject | Cancer | en_US |
dc.subject | Epithelial-mesenchymal transition | en_US |
dc.subject | HIF-1 alpha | en_US |
dc.subject | Hypoxia | en_US |
dc.subject | Metastasis | en_US |
dc.subject | Signaling pathway | en_US |
dc.title | Hypoxia-induced epithelial-mesenchymal transition in cancers : HIf-1 alpha and beyond | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 1 | - |
dc.identifier.epage | 11 | - |
dc.identifier.volume | 10 | - |
dc.identifier.doi | 10.3389/fonc.2020.00486 | - |
dcterms.abstract | Metastasis is the main cause of cancer-related mortality. Although the actual process of metastasis remains largely elusive, epithelial-mesenchymal transition (EMT) has been considered as a major event in metastasis. Besides, hypoxia is common in solid cancers and has been considered as an important factor for adverse treatment outcomes including metastasis. Since EMT and hypoxia potentially share several signaling pathways, many recent studies focused on investigate the issue of hypoxia-induced EMT. Among all potential mediators of hypoxia-induced EMT, hypoxia-inducible factor-1 alpha (HIF-1 alpha) has been studied extensively. Moreover, there are other potential mediators that may also contribute to the process. This review aims to summarize the recent reports on hypoxia-induced EMT by HIF-1 alpha or other potential mediators and provide insights for further investigations on this issue. Ultimately, better understanding of hypoxia-induced EMT may allow us to develop anti-metastatic strategies and improve treatment outcomes. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Frontiers in oncology, Apr. 2020, v. 10, 486, p. 1-11 | - |
dcterms.isPartOf | Frontiers in oncology | - |
dcterms.issued | 2020-04 | - |
dc.identifier.isi | WOS:000529032300001 | - |
dc.identifier.scopus | 2-s2.0-85083892942 | - |
dc.identifier.pmid | 32322559 | - |
dc.identifier.eissn | 2234-943X | - |
dc.identifier.artn | 486 | - |
dc.description.validate | 202008 bcrc | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Tam_Hypoxia-Induced_Epithelial-Mesenchymal_Cancers.pdf | 1.61 MB | Adobe PDF | View/Open |
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