Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/87761
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Biology and Chemical Technology | - |
dc.creator | Chow, JPH | - |
dc.creator | Cai, YJ | - |
dc.creator | Chow, DTL | - |
dc.creator | Chung, SHK | - |
dc.creator | Chau, KC | - |
dc.creator | Ng, KY | - |
dc.creator | Leung, OM | - |
dc.creator | Wong, RMH | - |
dc.creator | Law, AWL | - |
dc.creator | Leung, YO | - |
dc.creator | Kwok, SY | - |
dc.creator | Leung, YC | - |
dc.date.accessioned | 2020-08-19T06:26:48Z | - |
dc.date.available | 2020-08-19T06:26:48Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/87761 | - |
dc.language.iso | en | en_US |
dc.publisher | Public Library of Science | en_US |
dc.rights | © 2020 Chow et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en_US |
dc.rights | The following publication Chow JPH, Cai Y, Chow DTL, Chung SHK, Chau K-C, Ng K-Y, et al. (2020) A modified arginine-depleting enzyme NEI-01 inhibits growth of pancreatic cancer cells. PLoS ONE 15(4): e0231633. is available at https://dx.doi.org/10.1371/journal.pone.0231633 | en_US |
dc.title | A modified arginine-depleting enzyme NEI-01 inhibits growth of pancreatic cancer cells | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 1 | - |
dc.identifier.epage | 19 | - |
dc.identifier.volume | 15 | - |
dc.identifier.issue | 4 | - |
dc.identifier.doi | 10.1371/journal.pone.0231633 | - |
dcterms.abstract | Arginine deprivation cancer therapy targets certain types of malignancies with positive result in many studies and clinical trials. NEI-01 was designed as a novel arginine-depleting enzyme comprising an albumin binding domain capable of binding to human serum albumin to lengthen its half-life. In the present work, NEI-01 is shown to bind to serum albumin from various species, including mice, rat and human. Single intraperitoneal administration of NEI-01 to mice reduced plasma arginine to undetectable level for at least 9 days. Treatment of NEI-01 specifically inhibited cell viability of MIA PaCa-2 and PANC-1 cancer cell lines, which were ASS1 negative. Using a human pancreatic mouse xenograft model, NEI-01 treatment significantly reduced tumor volume and weight. Our data provides proof of principle for a cancer treatment strategy using NEI-01. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | PLoS one, 2020, v. 15, no. 4, e0231633, p. 1-19 | - |
dcterms.isPartOf | PLoS one | - |
dcterms.issued | 2020 | - |
dc.identifier.isi | WOS:000536673200019 | - |
dc.identifier.scopus | 2-s2.0-85084170551 | - |
dc.identifier.pmid | 32353864 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.artn | e0231633 | - |
dc.description.validate | 202008 bcrc | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Chow_Modified_Arginine-Depleting_Nei-01.pdf | 2.32 MB | Adobe PDF | View/Open |
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