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Title: Visuoauditory associative memory established with cholecystokinin under anesthesia is retrieved in behavioral contexts
Authors: Zhang, Z 
Zheng, XJ
Sun, WJ
Peng, YJ
Guo, YP
Lu, D 
Zheng, YL
Li, X 
Jendrichovsky, P
Tang, P
He, L
Li, M
Liu, Q
Xu, FQ
Ng, G 
Chen, X
He, JF 
Issue Date: 2020
Source: Journal of neuroscience, 4 Mar. 2020, v. 40, no. 10, p. 2025-2037
Abstract: Plastic change in neuronal connectivity is the foundation of memory encoding. It is not clear whether the changes during anesthesia can alter subsequent behavior. Here, we demonstrated that in male rodents under anesthesia, a visual stimulus (VS) was associated with electrical stimulation of the auditory cortex or natural auditory stimulus in the presence of cholecystokinin (CCK), which guided the animals' behavior in a two-choice auditory task. Auditory neurons became responsive to the VS after the pairings. Moreover, high-frequency stimulation of axon terminals of entorhinal CCK neurons in the auditory cortex enabled LTP of the visual response in the auditory cortex. Such pairing during anesthesia also generated VS-induced freezing in an auditory fear conditioning task. Finally, we verified that direct inputs from the entorhinal CCK neurons and the visual cortex enabled the above neural plasticity in the auditory cortex. Our findings suggest that CCK-enabled visuoauditory association during anesthesia can be translated to the subsequent behavior action.
Keywords: Auditory cortex
Entorhinal cortex
Memory encoding
Neural plasticity
Operant conditioning
Publisher: Society for Neuroscience
Journal: Journal of neuroscience 
ISSN: 0270-6474
EISSN: 1529-2401
DOI: 10.1523/JNEUROSCI.1673-19.2019
Rights: Copyright © 2020 Zhang et al.
This is an open-access article distributed under the terms of the Creative Commons Attribution License Creative Commons Attribution 4.0 International (, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
The following publication Zhang, Z., Zheng, X. J., Sun, W. J., Peng, Y. J., Guo, Y. P., Lu, D., ... & He, J. (2020). Visuoauditory associative memory established with cholecystokinin under anesthesia is retrieved in behavioral contexts. Journal of Neuroscience, 40(10), 2025-2037 is available at
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