Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/82180
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dc.contributorDepartment of Applied Biology and Chemical Technology-
dc.creatorHuang, H-
dc.creatorDong, N-
dc.creatorShu, LB-
dc.creatorLu, JY-
dc.creatorSun, QL-
dc.creatorChan, EWC-
dc.creatorChen, S-
dc.creatorZhang, R-
dc.date.accessioned2020-05-05T05:58:59Z-
dc.date.available2020-05-05T05:58:59Z-
dc.identifier.urihttp://hdl.handle.net/10397/82180-
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.rights© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., LtdThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricteduse, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rightsThe following publication Hong Huang, Ning Dong, Lingbin Shu, Jiayue Lu, Qiaoling Sun, Edward Wai-Chi Chan, Sheng Chen & Rong Zhang (2020) Colistin-resistance gene mcr in clinical carbapenem-resistant Enterobacteriaceae strains in China, 2014–2019, Emerging Microbes & Infections, 9:1,237-245 is available at https://dx.doi.org/10.1080/22221751.2020.1717380en_US
dc.subjectCarbapenem-resistant enterobacteriaceaeen_US
dc.subjectmcr-1en_US
dc.subjectColistinen_US
dc.subjectClinical usesen_US
dc.subjectChinaen_US
dc.titleColistin-resistance gene mcr in clinical carbapenem-resistant Enterobacteriaceae strains in China, 2014-2019en_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage237-
dc.identifier.epage245-
dc.identifier.volume9-
dc.identifier.issue1-
dc.identifier.doi10.1080/22221751.2020.1717380-
dcterms.abstractTo investigate whether introduction of colistin into the clinical settings selected colistin-resistant CRE, we performed molecular epidemiological study of 1868 CRE strains collected from different geographical locales in China during the period 2014-2019. 1755 (96.18%) isolates carried the carbapenemase genes bla(KPC) and bla(NDM); 14 Escherichia coli isolates (0.75%) carrying mcr-1 and bla(NDM) (MCR-CREC) were also identified. Importantly, the number and relative prevalence of MCR-CREC isolates increased from 5 (0.41%) to 9 (1.38%) after introduction of polymyxin into clinical practice. Consistently, results of genetic analysis indicated that MCR-CREC strains collected before December 2017 were genetically diverse, yet those collected after that date exhibited more closely related genetic profiles, indicating that specific MCR-CREC strains were rapidly selected as a result of increased usage of colistin in clinical settings. The resistance level of MCR-CREC isolates to colistin increased after the introduction of polymyxin into clinical use with the MIC to colistin from <2 mg/L in 80% strains to 2 mg/L in 100% strains. Further dissemination of MCR-CREC strains, which exhibit resistance to the last-line drugs of carbapenems and colistin, is expected to pose a severe threat to human health.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationEmerging microbes & infections, 2020, v. 9, no. 1, p. 237-245-
dcterms.isPartOfEmerging microbes & infections-
dcterms.issued2020-
dc.identifier.isiWOS:000510237300001-
dc.identifier.scopus2-s2.0-85078691115-
dc.identifier.pmid31996107-
dc.identifier.eissn2222-1751-
dc.description.validate202006 bcrc-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_Scopus/WOSen_US
dc.description.pubStatusPublisheden_US
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