Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/82166
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dc.contributorDepartment of Health Technology and Informatics-
dc.creatorAkbor, M-
dc.creatorHung, KF-
dc.creatorYang, YP-
dc.creatorChou, SJ-
dc.creatorTsai, PH-
dc.creatorChien, CS-
dc.creatorLin, LT-
dc.date.accessioned2020-05-05T05:58:56Z-
dc.date.available2020-05-05T05:58:56Z-
dc.identifier.issn1726-4901-
dc.identifier.urihttp://hdl.handle.net/10397/82166-
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.rightsCopyright © 2019, the Chinese Medical Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)en_US
dc.rightsThe following publication Akbor, M., Hung, K. F., Yang, Y. P., Chou, S. J., Tsai, P. H., Chien, C. S., & Lin, L. T. (2020). Immunotherapy orchestrates radiotherapy in composing abscopal effects: A strategic review in metastatic head and neck cancer. Journal of the Chinese Medical Association, 83(2), 113-116 is available at https://dx.doi.org/10.1097/JCMA.0000000000000234en_US
dc.subjectAbscopal effecten_US
dc.subjectCheckpoint inhibitoren_US
dc.subjectHead and neck canceren_US
dc.subjectImmunotherapyen_US
dc.subjectRadiotherapyen_US
dc.titleImmunotherapy orchestrates radiotherapy in composing abscopal effects : a strategic review in metastatic head and neck canceren_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage113-
dc.identifier.epage116-
dc.identifier.volume83-
dc.identifier.issue2-
dc.identifier.doi10.1097/JCMA.0000000000000234-
dcterms.abstractThe treatment of metastatic head and neck squamous cell carcinoma (HNSCC) with a combination of radiotherapy (RT) and immunotherapy can augment treatment response and symptomatic relief. Combination therapy can also trigger a non-targeted tumor control event called the abscopal effect. This effect can be demonstrated by treatment with anti-programmed death 1/programmed death ligand 1 (PD-L1) and anti-cytotoxic T-lymphocyte-associated antigen 4 antibodies in combination with hypofractionated RT. Individual studies and clinical trials have revealed that combination radio-immunotherapy improves overall treatment response by successful initiation of the abscopal effect, which extends the treatment effects to non-targeted lesions. Growing attention to the abscopal effect may inspire innovations in current RT toward more effective and less toxic radiobiological treatment modalities for advanced HNSCC. We review the latest findings on the abscopal effect with emphases on therapeutic modalities and potential applications for treating metastatic HNSCC.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationJournal of the Chinese Medical Association, 2020, v. 83, no. 2, p. 113-116-
dcterms.isPartOfJournal of the Chinese Medical Association-
dcterms.issued2020-
dc.identifier.isiWOS:000511978000004-
dc.identifier.scopus2-s2.0-85079017725-
dc.identifier.pmid31834023-
dc.identifier.eissn1728-7731-
dc.description.validate202006 bcrc-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_Scopus/WOSen_US
dc.description.pubStatusPublisheden_US
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