Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/82133
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dc.contributorDepartment of Biomedical Engineeringen_US
dc.creatorYang, Ten_US
dc.creatorDu, Zen_US
dc.creatorQiu, Hen_US
dc.creatorGao, Pen_US
dc.creatorZhao, Xen_US
dc.creatorWang, Hen_US
dc.creatorTu, Qen_US
dc.creatorXiong, Ken_US
dc.creatorHuang, Nen_US
dc.creatorYang, Zen_US
dc.date.accessioned2020-05-05T05:58:48Z-
dc.date.available2020-05-05T05:58:48Z-
dc.identifier.urihttp://hdl.handle.net/10397/82133-
dc.language.isoenen_US
dc.publisherKe Ai Publishing Communications Ltd.en_US
dc.rights© 2020 Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)en_US
dc.rightsThe following publication Yang, T., Du, Z., Qiu, H., Gao, P., Zhao, X., Wang, H., ... & Yang, Z. (2020). From surface to bulk modification: Plasma polymerization of amine-bearing coating by synergic strategy of biomolecule grafting and nitric oxide loading. Bioactive Materials, 5(1), 17-25, is available at https://doi.org/10.1016/j.bioactmat.2019.12.006en_US
dc.subjectAmine-bearing coatingen_US
dc.subjectBiomolecule graftingen_US
dc.subjectNitric oxide loadingen_US
dc.subjectSurface chemistryen_US
dc.subjectSynergic modificationen_US
dc.titleFrom surface to bulk modification : plasma polymerization of amine-bearing coating by synergic strategy of biomolecule grafting and nitric oxide loadingen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage17en_US
dc.identifier.epage25en_US
dc.identifier.volume5en_US
dc.identifier.issue1en_US
dc.identifier.doi10.1016/j.bioactmat.2019.12.006en_US
dcterms.abstractIntegration of two or more biomolecules with synergetic and complementary effects on a material surface can help to obtain multi-functions for various biomedical applications. However, the amounts of biomolecules integrated and their physiological functions are compromised due to the limited surface anchoring sites. Herein, we propose a novel concept of film engineering strategy “from surface to bulk synergetic modification”. This new concept is realized by employing the surface amine groups of plasma polymerized allylamine (PPAm) film for grafting a molecule e.g., thrombin inhibitor, bivalirudin (BVLD), meanwhile its bulk amine groups is used as a universal depot for storing and releasing therapeutic nitric oxide (NO) gas as supplement to the functions of BVLD. It is demonstrated that such a “from surface to bulk synergetic modification” film engineering can impart the modified-substrates with anti-platelet and anti-coagulant dual functions, giving rise to a highly endothelium-mimetic thromboresistant property. We believe that our research provides a very promising strategy to deliver multifunctional surface versatilely that require NO release in combination with other properties, which will find broad biomedical applications in blood-contacting devices, and et al. Moreover, it also provides a brand-new film engineering strategy for tailoring surface multi-functionalities of a wide range of materials.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationBioactive materials, Mar. 2020, v. 5, no. 1, p. 17-25en_US
dcterms.isPartOfBioactive materialsen_US
dcterms.issued2020-03-
dc.identifier.isiWOS:000517802700003-
dc.identifier.scopus2-s2.0-85077648494-
dc.identifier.eissn2452-199Xen_US
dc.description.validate202006 bcmaen_US
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumbera0596-n20, OA_Scopus/WOSen_US
dc.identifier.SubFormID438-
dc.description.fundingSourceSelf-fundeden_US
dc.description.pubStatusPublisheden_US
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