Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/82122
| Title: | Animal models of osteochondral defect for testing biomaterials | Authors: | Meng, X Ziadlou, R Grad, S Alini, M Wen, C Lai, Y Qin, L Zhao, Y Wang, X |
Issue Date: | 2020 | Source: | Biochemistry research international, 2020, v. 2020, 9659412 | Abstract: | The treatment of osteochondral defects (OCD) remains a great challenge in orthopaedics. Tissue engineering holds a good promise for regeneration of OCD. In the light of tissue engineering, it is critical to establish an appropriate animal model to evaluate the degradability, biocompatibility, and interaction of implanted biomaterials with host bone/cartilage tissues for OCD repair in vivo. Currently, model animals that are commonly deployed to create osteochondral lesions range from rats, rabbits, dogs, pigs, goats, and sheep horses to nonhuman primates. It is essential to understand the advantages and disadvantages of each animal model in terms of the accuracy and effectiveness of the experiment. Therefore, this review aims to introduce the common animal models of OCD for testing biomaterials and to discuss their applications in translational research. In addition, we have reviewed surgical protocols for establishing OCD models and biomaterials that promote osteochondral regeneration. For small animals, the non-load-bearing region such as the groove of femoral condyle is commonly chosen for testing degradation, biocompatibility, and interaction of implanted biomaterials with host tissues. For large animals, closer to clinical application, the load-bearing region (medial femoral condyle) is chosen for testing the durability and healing outcome of biomaterials. This review provides an important reference for selecting a suitable animal model for the development of new strategies for osteochondral regeneration. | Publisher: | Hindawi Limited | Journal: | Biochemistry research international | EISSN: | 2090-2247 | DOI: | 10.1155/2020/9659412 | Rights: | Copyright © 2020 Xiangbo Meng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The following publication Meng, X., Ziadlou, R., Grad, S., Alini, M., Wen, C., Lai, Y., ... & Wang, X. (2020). Animal Models of Osteochondral Defect for Testing Biomaterials. Biochemistry Research International, 2020, is available at https://doi.org/10.1155/2020/9659412 |
| Appears in Collections: | Journal/Magazine Article |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Meng_Animal_Models_Osteochondral.pdf | 1.64 MB | Adobe PDF | View/Open |
Access
View full-text via PolyU eLinks 
Page views
45
Last Week
3
3
Last month
Citations as of May 28, 2023
Downloads
37
Citations as of May 28, 2023
SCOPUSTM
Citations
36
Citations as of May 25, 2023
WEB OF SCIENCETM
Citations
31
Citations as of May 25, 2023
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.