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Title: Mechanism of controlled release of vancomycin from crumpled graphene oxides
Authors: He, X
Zhou, Z
Han, Z 
Zeng, Y
Chen, X
Su, J
Issue Date: 2019
Source: ACS omega, 2019, v. 4, no. 7, p. 12252-12258
Abstract: The physical and chemical interactions with vancomycin (VAN) were accessed between graphene oxide (GO) and crumpled graphene oxide (CGO) to present the possible loading and release mechanisms. The improved hydrophilicity and surface charge were found on CGO through water contact angle and ζ-potential measurements. Fourier transform infrared and X-ray photoelectron spectroscopies confirmed the attachment of VAN onto CGO or GO through Ï-πstacking and hydrogen bonding. Both CGO-VAN and GO-VAN drug complexes showed pH-controlled release property. The high VAN loading and delayed release in CGO-VAN system were mainly due to the crumpled morphology.
Publisher: American Chemical Society
Journal: ACS omega 
ISSN: 2470-1343
DOI: 10.1021/acsomega.9b00873
Rights: Copyright © 2019 American Chemical Society. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
The following publication He, X., Zhou, Z., Han, Z., Zeng, Y., Chen, X., & Su, J. (2019). Mechanism of Controlled Release of Vancomycin from Crumpled Graphene Oxides. ACS omega, 4(7), 12252-12258, is available at
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