Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/81764
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dc.contributorChinese Mainland Affairs Office-
dc.contributorDepartment of Applied Biology and Chemical Technology-
dc.creatorSun, QLen_US
dc.creatorWang, HYen_US
dc.creatorShu, LBen_US
dc.creatorDong, Nen_US
dc.creatorYang, Fen_US
dc.creatorZhou, HWen_US
dc.creatorChen, Sen_US
dc.creatorZhang, Ren_US
dc.date.accessioned2020-02-10T12:29:03Z-
dc.date.available2020-02-10T12:29:03Z-
dc.identifier.issn1664-302Xen_US
dc.identifier.urihttp://hdl.handle.net/10397/81764-
dc.language.isoenen_US
dc.publisherFrontiers Research Foundationen_US
dc.rightsCopyright © 2019 Sun, Wang, Shu, Dong, Yang, Zhou, Chen and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.rightsThe following publication Sun Q, Wang H, Shu L, Dong N, Yang F, Zhou H, Chen S and Zhang R (2019) Leclercia adecarboxylata From Human Gut Flora Carries mcr-4.3 and blaIMP-4-Bearing Plasmids. Front. Microbiol. 10:2805, 1-5 is available at https://dx.doi.org/10.3389/fmicb.2019.02805en_US
dc.subjectLeclercia adecarboxylataen_US
dc.subjectMcr-4en_US
dc.subject3en_US
dc.subjectGut floraen_US
dc.subjectCarbapenem resistanceen_US
dc.subjectColistin-susceptibilityen_US
dc.titleLeclercia adecarboxylata from human gut flora carries mcr-4.3 and bla(IMP-4)-bearing plasmidsen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage1en_US
dc.identifier.epage5en_US
dc.identifier.volume10en_US
dc.identifier.doi10.3389/fmicb.2019.02805en_US
dcterms.abstractA clinical Leclercia adecarboxylata strain harboring the mcr-4.3 and bla(IMP-4) genes was isolated from active rectal screening of carbapenem-resistant Enterobacteriaceae (CRE) in a patient. The isolate was found to harbor seven plasmids, including a 94,635 bp bla(IMP-4)-bearing IncN plasmid and a 9,782 bp mcr-4.3-bearing ColE10-type plasmid. The isolate was susceptible to colistin despite carrying the mcr-4.3 gene, suggesting that this MCR-4 variant may not be functional. Carriage of antibiotic resistance genes in human gut L. adecarboxylata strain suggests that close surveillance of resistance strains in the human gut flora should be included as a routine clinical practice to prevent occurrence of infections, especially among immunocompromised patients.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationFrontiers in microbiology, 5 Dec. 2019, v. 10, 2805, p. 1-5en_US
dcterms.isPartOfFrontiers in microbiologyen_US
dcterms.issued2019-
dc.identifier.isiWOS:000503474600001-
dc.identifier.scopus2-s2.0-85077276370-
dc.identifier.pmid31866974-
dc.identifier.artn2805en_US
dc.description.validate202002 bcrc-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_Scopus/WOSen_US
dc.description.pubStatusPublisheden_US
dc.description.oaCategoryCCen_US
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