Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/81759
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Biomedical Engineering | en_US |
dc.creator | Qiu, ZH | en_US |
dc.creator | Guo, JH | en_US |
dc.creator | Kala, S | en_US |
dc.creator | Zhu, JJ | en_US |
dc.creator | Xian, QX | en_US |
dc.creator | Qiu, WB | en_US |
dc.creator | Li, GF | en_US |
dc.creator | Zhu, T | en_US |
dc.creator | Meng, L | en_US |
dc.creator | Zhang, R | en_US |
dc.creator | Chan, HC | en_US |
dc.creator | Zheng, HR | en_US |
dc.creator | Sun, L | en_US |
dc.date.accessioned | 2020-02-10T12:29:01Z | - |
dc.date.available | 2020-02-10T12:29:01Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/81759 | - |
dc.language.iso | en | en_US |
dc.publisher | Cell Press | en_US |
dc.rights | © 2019 The Author(s). | en_US |
dc.rights | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | en_US |
dc.rights | The following publication Qiu, Z. H., Guo, J. H., Kala, S., Zhu, J. J., Xian, Q. X., Qiu, W. B., . . . Sun, L. (2019). The mechanosensitive ion channel piezo1 significantly mediates in vitro ultrasonic stimulation of neurons. iScience, 21, 448-457 is available at https://dx.doi.org/10.1016/j.isci.2019.10.037 | en_US |
dc.title | The mechanosensitive ion channel piezo1 significantly mediates in vitro ultrasonic stimulation of neurons | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 448 | en_US |
dc.identifier.epage | 457 | en_US |
dc.identifier.volume | 21 | en_US |
dc.identifier.doi | 10.1016/j.isci.2019.10.037 | en_US |
dcterms.abstract | Ultrasound brain stimulation is a promising modality for probing brain function and treating brain disease non-invasively and with high spatiotemporal resolution. However, the mechanism underlying its effects remains unclear. Here, we examine the role that the mouse piezo-type mechanosensitive ion channel component 1 (Piezo1) plays in mediating the in vitro effects of ultrasound in mouse primary cortical neurons and a neuronal cell line. We show that ultrasound alone could activate heterologous and endogenous Piezo1, initiating calcium influx and increased nuclear c-Fos expression in primary neurons but not when pre-treated with a Piezo1 inhibitor. We also found that ultrasound significantly increased the expression of the important proteins phospho-CaMKII, phospho-CREB, and c-Fos in a neuronal cell line, but Piezo1 knockdown significantly reduced this effect. Our findings demonstrate that the activity of mechanosensitive ion channels such as Piezo1 stimulated by ultrasound is an important contributor to its ability to stimulate cells in vitro. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | iScience, 22 Nov. 2019, v. 21, p. 448-457 | en_US |
dcterms.isPartOf | iScience | en_US |
dcterms.issued | 2019 | - |
dc.identifier.isi | WOS:000498899800035 | - |
dc.identifier.scopus | 2-s2.0-85074393161 | - |
dc.identifier.pmid | 31707258 | - |
dc.identifier.eissn | 2589-0042 | en_US |
dc.description.validate | 202002 bcrc | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | RGC-B1-010, OA_Scopus/WOS, a1632 | - |
dc.identifier.SubFormID | 45682 | - |
dc.description.fundingSource | RGC | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Qiu_Mechanosensitive_Ion_Channel.pdf | 2.75 MB | Adobe PDF | View/Open |
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