Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/81759
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dc.contributorDepartment of Biomedical Engineeringen_US
dc.creatorQiu, ZHen_US
dc.creatorGuo, JHen_US
dc.creatorKala, Sen_US
dc.creatorZhu, JJen_US
dc.creatorXian, QXen_US
dc.creatorQiu, WBen_US
dc.creatorLi, GFen_US
dc.creatorZhu, Ten_US
dc.creatorMeng, Len_US
dc.creatorZhang, Ren_US
dc.creatorChan, HCen_US
dc.creatorZheng, HRen_US
dc.creatorSun, Len_US
dc.date.accessioned2020-02-10T12:29:01Z-
dc.date.available2020-02-10T12:29:01Z-
dc.identifier.urihttp://hdl.handle.net/10397/81759-
dc.language.isoenen_US
dc.publisherCell Pressen_US
dc.rights© 2019 The Author(s).en_US
dc.rightsThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.rightsThe following publication Qiu, Z. H., Guo, J. H., Kala, S., Zhu, J. J., Xian, Q. X., Qiu, W. B., . . . Sun, L. (2019). The mechanosensitive ion channel piezo1 significantly mediates in vitro ultrasonic stimulation of neurons. iScience, 21, 448-457 is available at https://dx.doi.org/10.1016/j.isci.2019.10.037en_US
dc.titleThe mechanosensitive ion channel piezo1 significantly mediates in vitro ultrasonic stimulation of neuronsen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage448en_US
dc.identifier.epage457en_US
dc.identifier.volume21en_US
dc.identifier.doi10.1016/j.isci.2019.10.037en_US
dcterms.abstractUltrasound brain stimulation is a promising modality for probing brain function and treating brain disease non-invasively and with high spatiotemporal resolution. However, the mechanism underlying its effects remains unclear. Here, we examine the role that the mouse piezo-type mechanosensitive ion channel component 1 (Piezo1) plays in mediating the in vitro effects of ultrasound in mouse primary cortical neurons and a neuronal cell line. We show that ultrasound alone could activate heterologous and endogenous Piezo1, initiating calcium influx and increased nuclear c-Fos expression in primary neurons but not when pre-treated with a Piezo1 inhibitor. We also found that ultrasound significantly increased the expression of the important proteins phospho-CaMKII, phospho-CREB, and c-Fos in a neuronal cell line, but Piezo1 knockdown significantly reduced this effect. Our findings demonstrate that the activity of mechanosensitive ion channels such as Piezo1 stimulated by ultrasound is an important contributor to its ability to stimulate cells in vitro.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationiScience, 22 Nov. 2019, v. 21, p. 448-457en_US
dcterms.isPartOfiScienceen_US
dcterms.issued2019-
dc.identifier.isiWOS:000498899800035-
dc.identifier.scopus2-s2.0-85074393161-
dc.identifier.pmid31707258-
dc.identifier.eissn2589-0042en_US
dc.description.validate202002 bcrcen_US
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberRGC-B1-010, OA_Scopus/WOS, a1632-
dc.identifier.SubFormID45682-
dc.description.fundingSourceRGCen_US
dc.description.pubStatusPublisheden_US
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