Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/81693
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dc.contributorDepartment of Health Technology and Informatics-
dc.creatorXue, VW-
dc.creatorCheung, MT-
dc.creatorChan, PT-
dc.creatorLuk, LLY-
dc.creatorLee, VH-
dc.creatorAu, TC-
dc.creatorYu, AC-
dc.creatorCho, WCS-
dc.creatorTsang, HFA-
dc.creatorChan, AK-
dc.creatorWong, SCC-
dc.date.accessioned2020-02-10T12:28:40Z-
dc.date.available2020-02-10T12:28:40Z-
dc.identifier.urihttp://hdl.handle.net/10397/81693-
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.rightsOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Cre-ative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not per-mitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en_US
dc.rights© The Author(s) 2019en_US
dc.rightsThe following publication Xue, V.W., Cheung, M.T., Chan, P.T. et al. Non-invasive Potential Circulating mRNA Markers for Colorectal Adenoma Using Targeted Sequencing. Sci Rep 9, 12943 (2019), 1-10 is available at https://dx.doi.org/10.1038/s41598-019-49445-xen_US
dc.titleNon-invasive potential circulating mRNA markers for colorectal adenoma using targeted sequencingen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage1-
dc.identifier.epage10-
dc.identifier.volume9-
dc.identifier.doi10.1038/s41598-019-49445-x-
dcterms.abstractWe have developed an optimized protocol for plasma targeted mRNA sequencing in our previous study. Here, we performed plasma targeted mRNA sequencing for 40 colorectal adenoma patients and 39 colonoscopy-proven normal controls in order to find potential circulating mRNA markers for colorectal adenoma. Results showed that GSK3A and RHOA were differential expressed genes identified by a cut-off of fold change >2 and adjusted P value < 0.05. More detailed analysis showed that the expression of both GSK3A (0.01-fold with adjusted P < 1 x 10(-6)) and RHOA (0.35-fold with adjusted P < 0.01) in adenoma patients was significantly lower than those in normal healthy subjects. Based on the enrichment analysis of biological process for potential markers, we found that the regulation of programmed cell death (GO: 0043067; GO: 0043069), regulation of cell death (GO: 0010941; GO: 0060548) and cell differentiation (GO: 0021861) were the main processes involved in adenoma formation. In summary, this study is a cutting-edge research on the detection of plasma mRNA in colorectal adenoma patients and normal healthy subjects.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationScientific reports, 10 Sept. 2019, v. 9, 12943, p. 1-10-
dcterms.isPartOfScientific reports-
dcterms.issued2019-
dc.identifier.isiWOS:000484984700018-
dc.identifier.eissn2045-2322-
dc.identifier.artn12943-
dc.description.validate202002 bcrc-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_Scopus/WOSen_US
dc.description.pubStatusPublisheden_US
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