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Title: LNRLMI : linear neighbour representation for predicting lncRNA-miRNA interactions
Authors: Wong, L
Huang, YA 
You, ZH
Chen, ZH
Cao, MY
Issue Date: 2019
Source: Journal of cellular and molecular medicine, 2019, p. 1-9
Abstract: LncRNA and miRNA are key molecules in mechanism of competing endogenous RNAs(ceRNA), and their interactions have been discovered with important roles in gene regulation. As supplementary to the identification of lncRNA-miRNA interactions from CLIP-seq experiments, in silico prediction can select the most potential candidates for experimental validation. Although developing computational tool for predicting lncRNA-miRNA interaction is of great importance for deciphering the ceRNA mechanism, little effort has been made towards this direction. In this paper, we propose an approach based on linear neighbour representation to predict lncRNA-miRNA interactions (LNRLMI). Specifically, we first constructed a bipartite network by combining the known interaction network and similarities based on expression profiles of lncRNAs and miRNAs. Based on such a data integration, linear neighbour representation method was introduced to construct a prediction model. To evaluate the prediction performance of the proposed model, k-fold cross validations were implemented. As a result, LNRLMI yielded the average AUCs of 0.8475 +/- 0.0032, 0.8960 +/- 0.0015 and 0.9069 +/- 0.0014 on 2-fold, 5-fold and 10-fold cross validation, respectively. A series of comparison experiments with other methods were also conducted, and the results showed that our method was feasible and effective to predict lncRNA-miRNA interactions via a combination of different types of useful side information. It is anticipated that LNRLMI could be a useful tool for predicting non-coding RNA regulation network that lncRNA and miRNA are involved in.
Keywords: CeRNA network
Expression profile
Link prediction
LncRNA-miRNA interaction
Publisher: Wiley-Blackwell
Journal: Journal of cellular and molecular medicine 
ISSN: 1582-1838
EISSN: 1582-4934
DOI: 10.1111/jcmm.14583
Rights: This is an open access article under the terms of the Creative Commons Attribution License (, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
© 2019 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.
The following publication Wong, L., Huang, Y. A., You, Z. H., Chen, Z. H., & Cao, M. Y. (2019). LNRLMI : linear neighbour representation for predicting lncRNA-miRNA interactions. Journal of Cellular and Molecular Medicine, 1-9 is available at
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