Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/81682
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dc.contributorDepartment of Rehabilitation Sciencesen_US
dc.creatorVanicek, Ten_US
dc.creatorKranz, GSen_US
dc.creatorVyssoki, Ben_US
dc.creatorKomorowski, Aen_US
dc.creatorFugger, Gen_US
dc.creatorHoflich, Aen_US
dc.creatorMicskei, Zen_US
dc.creatorMilovic, Sen_US
dc.creatorLanzenberger, Ren_US
dc.creatorEckert, Aen_US
dc.creatorKasper, Sen_US
dc.creatorFrey, Ren_US
dc.date.accessioned2020-02-10T12:28:37Z-
dc.date.available2020-02-10T12:28:37Z-
dc.identifier.issn0001-690Xen_US
dc.identifier.urihttp://hdl.handle.net/10397/81682-
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.rights©2019 The Authors. Acta Psychiatrica Scandinavica published by John Wiley & Sons Ltden_US
dc.rightsAll rights reserveden_US
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.en_US
dc.rightsThe following publication Vanicek, T., Kranz, G. S., Vyssoki, B., Komorowski, A., Fugger, G., Hoflich, A., . . . Frey, R. (2019). Repetitive enhancement of serum BDNF subsequent to continuation ECT. Acta Psychiatrica Scandinavica, 140(5), 426-434 is available at https://dx.doi.org/10.1111/acps.13080en_US
dc.subjectDepressionen_US
dc.subjectUnipolar and bipolar affective disorderen_US
dc.subjectContinuation electroconvulsive therapyen_US
dc.subjectBrain-derived neurotrophic factoren_US
dc.titleRepetitive enhancement of serum BDNF subsequent to continuation ECTen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage426en_US
dc.identifier.epage434en_US
dc.identifier.volume140en_US
dc.identifier.issue5en_US
dc.identifier.doi10.1111/acps.13080en_US
dcterms.abstractIntroduction: Continuation electroconvulsive therapy (c-ECT) is highly effective for the prevention of depressive symptom relapse. There is a lack of understanding, about how c-ECT works in humans, particularly with regard to its effects on brain derived neurotrophic factor (BDNF) concentrations. Here, we aimed to close a gap in the literature by evaluating BDNF levels in patients receiving c-ECT.en_US
dcterms.abstractMethods: We included 13 patients with either unipolar or bipolar depression (mean age +/- SD: 55.5 +/- 17.1; f/m: 10/3; unipolar/bipolar: 10/3) who received between one and four c-ECT (average per patient: 2.8). Serum BDNF (sBDNF) levels were assessed before and after each c-ECT sessions. Clinical assessments were also administered both before and after treatment.en_US
dcterms.abstractResults: Our analysis revealed a significant increase in sBDNF after each treatment (c-ECT 1-3: P < 0.001, c-ECT 4: P = 0.018). The application of multiple c-ECT treatments was not, however, associated with further sBDNF enhancements. Psychometric scores were not significantly altered following c-ECT.en_US
dcterms.abstractDiscussion: An increase in sBDNF concentrations subsequent to c-ECT parallel data from the animal literature, which has linked regularly applied electrical stimulation to neuroplastic processes. This finding suggests a relationship between ECT-induced sBDNF concentrations and (sustained) remission status, considering a stable clinical condition across c-ECT.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationActa psychiatrica Scandinavica, Nov. 2019, v. 140, no. 5, p. 426-434en_US
dcterms.isPartOfActa psychiatrica Scandinavicaen_US
dcterms.issued2019-11-
dc.identifier.isiWOS:000486279700001-
dc.identifier.scopus2-s2.0-85073791232-
dc.identifier.eissn1600-0447en_US
dc.description.validate202002 bcrcen_US
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumbera0723-n08, OA_Scopus/WOSen_US
dc.description.fundingSourceOthersen_US
dc.description.fundingTextAustrian National Bank (P23021)en_US
dc.description.pubStatusPublisheden_US
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