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Title: Worsen depression after viscosupplementation treatment for geriatric people with knee osteoarthritis?
Authors: Chen, YP
Wang, SM 
Wu, Y
Lin, HY
Wu, CC
Chuang, TY
Ho, WP
Kuo, YJ
Leu, TH
Lin, CY 
Issue Date: 2018
Source: International journal of clinical and health psychology, 2018, v. 19, no. 1, p. 31-40
Abstract: Background/objective: Knee osteoarthritis (OA) in older people may result in psychological impairment, including anxiety and depression. This study investigates the effect of intraarticular hyaluronic acid injection (IAHA) on geriatric patients with OA.
Method: A total of 102 geriatric patients with knee OA undergoing IAHA were prospectively enrolled in this study. Geriatric Depression Scale (GDS), State-Trait Anxiety Inventory (STAI), Western Ontario and McMaster University Osteoarthritis Index (WOMAC) and the International Knee Documentation Committee Subjective Knee Evaluation Form (IKDC), and Visual Analogue Scale (VAS) for pain were recorded. All outcomes were measured at baseline before injection and during two, four, and six month follow-ups.
Results: IAHA had a significant short-term effect, relieving pain at the two month follow-up, but the effect was weaker at the four month follow-up. Both IKDC and WOMAC scores were significantly improved at the two month follow-up. Viscosupplementation did not improve STAI. GDS exhibited significant deterioration at the four month follow-up.
Conclusions: Although IAHA for the treatment of OA provided short-term efficiency, it had no effects on anxiety and increased depression of geriatric people. Health education should be provided with caution before viscosupplementation treatment to manage expectations of the efficacy of treatment for geriatric OA patients.
Keywords: Depression
Hyaluronic acid
Publisher: Elsevier
Journal: International journal of clinical and health psychology 
ISSN: 1697-2600
DOI: 10.1016/j.ijchp.2018.10.001
Rights: © 2018 Asociaci´on Espa˜nola de Psicolog´ıa Conductual. Published by Elsevier Espa˜na, S.L.U. This is an open access article under the CC BY-NC-ND license (
The following publication Chen, Y. P., Wang, S. M., Wu, Y., Lin, H. Y., Wu, C. C., Chuang, T. Y., ... & Lin, C. Y. (2019). Worsen depression after viscosupplementation treatment for geriatric people with knee osteoarthritis?. International Journal of Clinical and Health Psychology, 19(1), 31-40 is available at
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