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dc.contributorDepartment of Rehabilitation Sciencesen_US
dc.creatorSpies, Men_US
dc.creatorKlobl, Men_US
dc.creatorHoflich, Aen_US
dc.creatorHummer, Aen_US
dc.creatorVanicek, Ten_US
dc.creatorMichenthaler, Pen_US
dc.creatorKranz, GSen_US
dc.creatorHahn, Aen_US
dc.creatorWinkler, Den_US
dc.creatorWindischberger, Cen_US
dc.creatorKasper, Sen_US
dc.creatorLanzenberger, Ren_US
dc.publisherNature Publishing Groupen_US
dc.rightsOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
dc.rights© The Author(s) 2019en_US
dc.rightsThe following publication Spies, M., Klobl, M., Hoflich, A., Hummer, A., Vanicek, T., Michenthaler, P., . . . Lanzenberger, R. (2019). Association between dynamic resting-state functional connectivity and ketamine plasma levels in visual processing networks. Scientific Reports, 9, 11484, 1-13 is available at
dc.titleAssociation between dynamic resting-state functional connectivity and ketamine plasma levels in visual processing networksen_US
dc.typeJournal/Magazine Articleen_US
dcterms.abstractNumerous studies demonstrate ketamine's influence on resting-state functional connectivity (rsFC). Seed-based and static rsFC estimation methods may oversimplify FC. These limitations can be addressed with whole-brain, dynamic rsFC estimation methods. We assessed data from 27 healthy subjects who underwent two 3T resting-state fMRI scans, once under subanesthetic, intravenous esketamine and once under placebo, in a randomized, cross-over manner. We aimed to isolate only highly robust effects of esketamine on dynamic rsFC by using eight complementary methodologies derived from two dynamic rsFC estimation methods, two functionally defined atlases and two statistical measures. All combinations revealed a negative influence of esketamine on dynamic rsFC within the left visual network and inter-hemispherically between visual networks (p < 0.05, corrected), hereby suggesting that esketamine's influence on dynamic rsFC is highly stable in visual processing networks. Our findings may be reflective of ketamine's role as a model for psychosis, a disorder associated with alterations to visual processing and impaired inter-hemispheric connectivity. Ketamine is a highly effective antidepressant and studies have shown changes to sensory processing in depression. Dynamic rsFC in sensory processing networks might be a promising target for future investigations of ketamine's antidepressant properties. Mechanistically, sensitivity of visual networks for esketamine's effects may result from their high expression of NMDA-receptors.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationScientific reports, 2019, v. 9, 11484, p. 1-13en_US
dcterms.isPartOfScientific reportsen_US
dc.description.validate201909 bcrcen_US
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumbera0749-n02, OA_Scopus/WOSen_US
dc.description.fundingTextAustrian National Bank (ÖNB, P 14193) and Austrian Science Fund (FWF, KLI 516)en_US
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