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Title: Corneal biomechanical properties characterization using air-jet indentation based Optical Coherence Tomography system (AIOCT)
Authors: Wang, LK 
Zhang, JY 
Li, TJ 
Zhang, XY
Tian, L 
Zheng, YP 
Issue Date: 2019
Source: MATEC Web of conferences, 2019, v. 256, 01004, p. 1-7
Abstract: We proposed a novel method together with system to quantify the corneal biomechanics. The objectives of this study are to develop a method to measure the corneal biomechanical properties in vivo and to evaluate the performance of AIOCT system. A novel AIOCT system was established and a mathematical model was built on the basis of the current air-jet indentation method. Experiments were performed to evaluate the mechanical properties of eleven custom-made silicone corneal mimicking phantoms by the AIOCT system under different intraocular pressures ( IOP). The results were then compared with those measured by the standard mechanical tensile test and indentation test. The phantom's moduli were ranged from 0.08 to 1.03 MPa according to the tensile and indentation test. The elastic moduli of corneal silicone phantoms ( E-airjet) were measured using the AIOCT system with the proposed mathematical model at four IOPs ( 0.6, 15.3, 29.8, and 44.7 mmHg). The E-airjet were agreed well with the corresponding moduli ( E-tensile) measured by the tensile test ( E-airjet = 1.188 E-tensile, R-2 = 0.925). The preliminary results showed that this technique was capable of measuring corneal biomechanical properties in vivo and it may provide a clinical potential non-invasive and non-contact means to the diagnosis of keratoconus suspects in the future.
Publisher: EDP Sciences
Journal: MATEC Web of conferences 
ISSN: 2261-236X
DOI: 10.1051/matecconf/201925601004
Description: 5th International Conference on Mechatronics and Mechanical Engineering (ICMME), Nov 10-12, 2018, China Univ Geosciences, Wuhan, People's Republic of China
Rights: © The Authors, published by EDP Sciences. This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (
The following publication Wang, L. K., Zhang, J. Y., Li, T. J., Zhang, X. Y., Tian, L., & Zheng, Y. P. (2019). Corneal Biomechanical Properties Characterization Using Air-jet Indentation Based Optical Coherence Tomography System (AIOCT). In MATEC Web of Conferences (Vol. 256, p. 01004). EDP Sciences is available at
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