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Title: Prevalence of extended spectrum beta-lactamase (ESBL) and AmpC beta-lactamase producing bacteria in urinary tract infection patients in Bangladesh
Authors: Mitu, FS
Al Maruf, MA 
Mahanty, A 
Huda, AKMN
Khan, SA
Rahman, MM
Issue Date: 2019
Source: Malaysian journal of microbiology, 2019, v. 15, no. 3, p. 204-212
Abstract: Aims: This study aimed to determine the prevalence of pathogens in urinary tract and their antimicrobial susceptibilities, based on extended-spectrum beta-lactamase (ESBL) and AmpC beta-lactamase production in Bangladesh.
Methodology and results: The prevalence of pathogenic microorganisms in urinary tract and their antimicrobial resistance patterns were identified in 200 isolates from patients with urinary tract infections. Combined disc diffusion was performed to identify the presence of ESBL-producing strains. Moreover, disc approximation assay, disc potentiation test and double disc synergy test were performed to determine the presence of AmpC beta-lactamase producing bacterial strains. This study demonstrated a higher prevalence of UTIs in females (83.5%) than in males (16.5%). The most common pathogen was found Escherichia coli (44.5%), followed by Enterococcus fecalis (24%), Klebsiella pneumoniae (7.5%), Staphylococcus aureus (6%), Pseudomonas aeruginosa (5.5%) and Staphylococcus saprophyticus (4.5%). ESBL and AmpC beta-lactamase production occurred more frequently in E. coli (25.84%) and P. aeruginosa (100%) respectively.
Conclusion, significance and impact of study: The result of this study would provide physicians with important information which help them to make a judicious choice of antibiotics for therapeutic purposes. However, it is emphasized that continuous surveillance of antibiogram of medically important organisms causing UTI is necessary for adopting a rational antibiotic policy in the country.
Keywords: Urinary tract infection
Antibiotic resistance
Publisher: Malaysian Society for Microbiology
Journal: Malaysian journal of microbiology 
ISSN: 1823-8262
EISSN: 2231-7538
DOI: 10.21161/mjm.180193
Rights: This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License (
The following publication Mitu, F. S., Al Maruf, M. A., Mahanty, A., Huda, A. K. M. N, Khan, S. A., … & Rahman, M. M. (2019). Prevalence of extended spectrum beta-lactamase (ESBL) and AmpC beta-lactamase producing bacteria in urinary tract infection patients in Bangladesh. Malaysian journal of microbiology, 15(3), 204-212 is available at
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