Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/81096
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Biology and Chemical Technology | - |
dc.contributor | Chinese Mainland Affairs Office | - |
dc.creator | Liu, R | - |
dc.creator | Chan, BD | - |
dc.creator | Mok, DKW | - |
dc.creator | Lee, CS | - |
dc.creator | Tai, WCS | - |
dc.creator | Chen, SB | - |
dc.date.accessioned | 2019-07-29T03:17:54Z | - |
dc.date.available | 2019-07-29T03:17:54Z | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | http://hdl.handle.net/10397/81096 | - |
dc.language.iso | en | en_US |
dc.publisher | Molecular Diversity Preservation International | en_US |
dc.rights | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | en_US |
dc.rights | The following publication Liu, R.; Dow Chan, B.; Mok, D. .-W.; Lee, C.-S.; Tai, W. .-S.; Chen, S. Arnicolide D, from the herb Centipeda minima, Is a Therapeutic Candidate against Nasopharyngeal Carcinoma. Molecules 2019, 24, 1908, 15 pages is available at https://dx.doi.org/10.3390/molecules24101908 | en_US |
dc.subject | Arnicolide D | en_US |
dc.subject | NPC | en_US |
dc.subject | Anti-proliferation | en_US |
dc.subject | Cell cycle arrest | en_US |
dc.subject | Apoptosis induction | en_US |
dc.title | Arnicolide D, from the herb centipeda minima, is a therapeutic candidate against nasopharyngeal carcinoma | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 1 | - |
dc.identifier.epage | 15 | - |
dc.identifier.volume | 24 | - |
dc.identifier.issue | 10 | - |
dc.identifier.doi | 10.3390/molecules24101908 | - |
dcterms.abstract | Nasopharyngeal carcinoma (NPC) is a high morbidity and mortality cancer with an obvious racial and geographic bias, particularly endemic to Southeast China. Our previous studies demonstrated that Centipeda minima extract (CME) exhibited anti-cancer effects in human NPC cell lines. Arnicolide C and arnicolide D are sesquiterpene lactones isolated from Centipeda minima. In this study, for the first time, we investigated their anti-NPC effects and further explored the related molecular mechanisms. The effects of both arnicolide C and arnicolide D were tested in NPC cells CNE-1, CNE-2, SUNE-1, HONE1, and C666-1. The results showed that the two compounds inhibited NPC cell viability in a concentration- and time-dependent manner. As the inhibitory effect of arnicolide D was the more pronounced of the two, our following studies focused on this compound. Arnicolide D could induce cell cycle arrest at G(2)/M, and induce cell apoptosis. The molecular mechanism of cell cycle regulation and apoptosis induction was investigated, and the results showed that arnicolide D could downregulate cyclin D3, cdc2, p-PI3K, p-AKT, p-mTOR, and p-STAT3, and upregulate cleaved PARP, cleaved caspase 9, and Bax. Regulation of cyclin B1, cdk6, and Bcl-2 expression by arnicolide D showed dynamic changes according to dose and time. Taken together, arnicolide D modulated the cell cycle, activated the caspase signaling pathway, and inhibited the PI3K/AKT/mTOR and STAT3 signaling pathways. These findings provide a solid base of evidence for arnicolide D as a lead compound for further development, and act as proof for the viability of drug development from traditional Chinese medicines. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Molecules, 2 May 2019, v. 24, no. 10, 1908, p. 1-15 | - |
dcterms.isPartOf | Molecules | - |
dcterms.issued | 2019 | - |
dc.identifier.isi | WOS:000470996600066 | - |
dc.identifier.pmid | 31108969 | - |
dc.identifier.artn | 1908 | - |
dc.description.validate | 201907 bcrc | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Liu_D_Centipeda_Is.pdf | 2.8 MB | Adobe PDF | View/Open |
Page views
129
Last Week
0
0
Last month
Citations as of Oct 13, 2024
Downloads
80
Citations as of Oct 13, 2024
SCOPUSTM
Citations
30
Citations as of Oct 17, 2024
WEB OF SCIENCETM
Citations
29
Citations as of Oct 17, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.