Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/80468
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dc.contributorDepartment of Health Technology and Informatics-
dc.creatorKhan, MZI-
dc.creatorTam, SY-
dc.creatorLaw, HKW-
dc.date.accessioned2019-03-26T09:17:23Z-
dc.date.available2019-03-26T09:17:23Z-
dc.identifier.urihttp://hdl.handle.net/10397/80468-
dc.language.isoenen_US
dc.publisherFrontiers Research Foundationen_US
dc.rightsCopyright © 2019 Islam Khan, Tam and Law. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.oen_US
dc.rightsThe following publication Khan, M. Z. I., Tam, S. Y., & Law, H. K. W. (2019). Autophagy-modulating long non-coding RNAs (LncRNAs) and their molecular events in cancer. Frontiers in Genetics, 9, 750, 1-11 is available at https://dx.doi.org/10.3389/fgene.2018.00750en_US
dc.subjectAutophagyen_US
dc.subjectLong non-coding RNAsen_US
dc.subjectCanceren_US
dc.subjectTherapyen_US
dc.subjectBiomarkersen_US
dc.titleAutophagy-modulating long non-coding RNAs (LncRNAs) and their molecular events in canceren_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage1en_US
dc.identifier.epage11en_US
dc.identifier.volume9en_US
dc.identifier.doi10.3389/fgene.2018.00750en_US
dcterms.abstractCancer is a global threat of health. Cancer incidence and death is also increasing continuously because of poor understanding of diseases. Although, traditional treatments (surgery, radiotherapy, and chemotherapy) are effective against primary tumors, death rate is increasing because of metastasis development where traditional treatments have failed. Autophagy is a conserved regulatory process of eliminating proteins and damaged organelles. Numerous research revealed that autophagy has dual sword mechanisms including cancer progressions and suppressions. In most of the cases, it maintains homeostasis of cancer microenvironment by providing nutritional supplement under starvation and hypoxic conditions. Over the past few decades, stunning research evidence disclosed significant roles of long non-coding RNAs (lncRNAs) in the regulation of autophagy. LncRNAs are RNA containing more than 200 nucleotides, which have no protein-coding ability but they are found to be expressed in most of the cancers. It is also proved that, autophagy-modulating lncRNAs have significant impacts on pro-survival or pro-death roles in cancers. In this review, we highlighted the recently identified autophagy-modulating lncRNAs, their signaling transduction in cancer and mechanism in cancer. This review will explore newly emerging knowledge of cancer genetics and it may provide novel targets for cancer therapy.-
dcterms.accessRightsopen access-
dcterms.bibliographicCitationFrontiers in genetics, 14 Jan. 2019, v. 9, 750, p. 1-11-
dcterms.isPartOfFrontiers in genetics-
dcterms.issued2019-01-14-
dc.identifier.isiWOS:000455671000001-
dc.identifier.scopus2-s2.0-85064414815-
dc.identifier.eissn1664-8021en_US
dc.identifier.artn750en_US
dc.description.validate201903 bcrc-
dc.description.oaVersion of Record-
dc.identifier.FolderNumbera0677-n01-
dc.identifier.SubFormID873-
dc.description.fundingSourceOthers-
dc.description.fundingTextThis work was supported by Departmental Start-up and Seed Funding for HL, and Departmental Postgraduate Funds for MK and ST, The Hong Kong Polytechnic University.-
dc.description.pubStatusPublished-
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